木糖苷的合成及其生物医学应用
Synthesis and biomedical applications of xylosides.
作者信息
Kalita Mausam, Quintero Maritza V, Raman Karthik, Tran Vy M, Kuberan Balagurunathan
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
出版信息
Methods Mol Biol. 2015;1229:517-28. doi: 10.1007/978-1-4939-1714-3_40.
Xylosides modulate the biosynthesis of sulfated glycosaminoglycans (GAGs) in various cell types. A new class of xylosides called "click-xylosides" has been synthesized for their biostability, ease of chemical synthesis, and tunable sulfated GAG biogenesis in vitro and in vivo. These click-xylosides have several therapeutic and biomedical applications in the regulation of angiogenesis, tumor inhibition, and regeneration. This protocol focuses on the synthesis of click-xylosides, their cellular priming activities, and biomedical applications.
木糖苷可调节多种细胞类型中硫酸化糖胺聚糖（GAGs）的生物合成。一类名为“点击木糖苷”的新型木糖苷已被合成，因其具有生物稳定性、易于化学合成以及在体外和体内可调节硫酸化GAG生物合成的特性。这些点击木糖苷在血管生成调节、肿瘤抑制和再生方面具有多种治疗和生物医学应用。本方案重点介绍点击木糖苷的合成、其细胞启动活性及生物医学应用。
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