Kalita Mausam, Quintero Maritza V, Raman Karthik, Tran Vy M, Kuberan Balagurunathan
Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
Methods Mol Biol. 2015;1229:517-28. doi: 10.1007/978-1-4939-1714-3_40.
Xylosides modulate the biosynthesis of sulfated glycosaminoglycans (GAGs) in various cell types. A new class of xylosides called "click-xylosides" has been synthesized for their biostability, ease of chemical synthesis, and tunable sulfated GAG biogenesis in vitro and in vivo. These click-xylosides have several therapeutic and biomedical applications in the regulation of angiogenesis, tumor inhibition, and regeneration. This protocol focuses on the synthesis of click-xylosides, their cellular priming activities, and biomedical applications.
木糖苷可调节多种细胞类型中硫酸化糖胺聚糖（GAGs）的生物合成。一类名为“点击木糖苷”的新型木糖苷已被合成，因其具有生物稳定性、易于化学合成以及在体外和体内可调节硫酸化GAG生物合成的特性。这些点击木糖苷在血管生成调节、肿瘤抑制和再生方面具有多种治疗和生物医学应用。本方案重点介绍点击木糖苷的合成、其细胞启动活性及生物医学应用。
