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Modulation of immune response against tumor cells by the in vivo administration of an autoreactive Th clone.通过体内给予自身反应性Th克隆来调节针对肿瘤细胞的免疫反应。
Jpn J Cancer Res. 1989 Nov;80(11):1106-12. doi: 10.1111/j.1349-7006.1989.tb02266.x.
2
MHC-restricted minimal regulatory circuit initiated by a class II-autoreactive T cell clone.由II类自身反应性T细胞克隆启动的MHC限制的最小调节回路。
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Immunoregulatory pathways in adult responder mice. III. Establishment of a GAT-specific suppressor T cell clone from GAT-tolerant responders which afferently regulates DTH responses.成年反应小鼠中的免疫调节途径。III. 从对谷氨酸-丙氨酸-酪氨酸（GAT）耐受的反应小鼠中建立GAT特异性抑制性T细胞克隆，该克隆通过传入调节迟发型超敏反应（DTH）。
J Mol Cell Immunol. 1985;2(1):1-13.
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T cell regulation of B cell activation. Lyt-1+,2-T cells modify the MHC-restricted function of heterogeneous and cloned T suppressor cells.T细胞对B细胞活化的调节。Lyt-1 +、2 - T细胞改变异质性和克隆化T抑制细胞的MHC限制性功能。
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Reactivity of Ly-2+ T cells against 2,4,6-trinitrophenyl (TNP)-modified syngeneic stimulator cells: specificity, frequency of interleukin 2-producing Ly-2+ helper T cells and clonal segregation from Ly-2+ cytotoxic T lymphocytes.Ly-2⁺ T细胞对2,4,6-三硝基苯（TNP）修饰的同基因刺激细胞的反应性：特异性、产生白细胞介素2的Ly-2⁺辅助性T细胞的频率以及与Ly-2⁺细胞毒性T淋巴细胞的克隆分离
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T cell regulation of B cell activation. I-A-restricted T suppressor cells inhibit the major histocompatibility complex-restricted interactions of T helper cells with B cells and accessory cells.T细胞对B细胞激活的调节作用。I-A限制性T抑制细胞抑制T辅助细胞与B细胞及辅助细胞之间主要组织相容性复合体限制性相互作用。
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本文引用的文献

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Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts.同种移植中的免疫机制。II. 肿瘤同种移植物刺激的淋巴细胞免疫活性的定量测定。
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Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.用环磷酰胺进行化学免疫疗法并过继转移同基因Lyt-1+2-淋巴细胞根除播散性小鼠白血病
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3
Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.用单克隆抗体GK1.5鉴定的小鼠T细胞表面分子L3T4的特性：L3T4与人Leu-3/T4分子的相似性
J Immunol. 1983 Nov;131(5):2445-51.
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T cell-mediated immunity to oncornavirus-induced tumors. I. Ly phenotype of precursor and effector cytolytic T lymphocytes.对致癌RNA病毒诱导肿瘤的T细胞介导免疫。I. 前体细胞毒性T淋巴细胞和效应细胞毒性T淋巴细胞的Ly表型
J Immunol. 1980 Feb;124(2):846-50.
5
The role of tumor-specific Lyt-1+2- T cells in eradicating tumor cells in vivo. I. Lyt-1+2- T cells do not necessarily require recruitment of host's cytotoxic T cell precursors for implementation of in vivo immunity.肿瘤特异性Lyt-1⁺2⁻ T细胞在体内清除肿瘤细胞中的作用。I. Lyt-1⁺2⁻ T细胞在实施体内免疫时不一定需要募集宿主的细胞毒性T细胞前体。
J Immunol. 1984 Sep;133(3):1671-6.
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Regulatory circuits and antibody responses.调节回路与抗体反应。
Eur J Immunol. 1980 Jan;10(1):1-11. doi: 10.1002/eji.1830100102.
7
Immunological studies on mouse mammary tumors. VI. Further characterization of a mammary tumor antigen and its distribution in lymphatic cells of allogeneic mice.小鼠乳腺肿瘤的免疫学研究。VI. 乳腺肿瘤抗原的进一步特性及其在同种异体小鼠淋巴细胞中的分布。
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8
Cell-mediated immune reaction against tumors induced by oncornaviruses. II. Nature of the effector cells in tumor-cell cytolysis.针对肿瘤病毒诱导的肿瘤的细胞介导免疫反应。II. 肿瘤细胞溶解中效应细胞的性质。
Int J Cancer. 1973 Mar 15;11(2):426-32. doi: 10.1002/ijc.2910110220.
9
Evidence for in vivo protection against murine-sarcoma virus-induced tumors by T lymphocytes from immune animals.来自免疫动物的T淋巴细胞对鼠肉瘤病毒诱导的肿瘤具有体内保护作用的证据。
J Immunol. 1974 Feb;112(2):533-9.
10
Antigenic cross-reactivity between primary spontaneous mouse mammary tumors and their transplantable ascites tumors.原发性自发性小鼠乳腺肿瘤与其可移植腹水肿瘤之间的抗原交叉反应性。
Cancer Res. 1971 Nov;31(11):1682-9.

通过体内给予自身反应性Th克隆来调节针对肿瘤细胞的免疫反应。

Modulation of immune response against tumor cells by the in vivo administration of an autoreactive Th clone.

作者信息

Kubo M, Sano K, Fujisawa I, Asano Y, Tada T

机构信息

Department of Immunology, Faculty of Medicine, University of Tokyo.

出版信息

Jpn J Cancer Res. 1989 Nov;80(11):1106-12. doi: 10.1111/j.1349-7006.1989.tb02266.x.

DOI:10.1111/j.1349-7006.1989.tb02266.x
PMID:2532633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917916/
Abstract

The immunization of C3H mice with irradiated syngeneic MM48 tumor cells induced specific tumor-neutralizing cells (TNC). The TNC activity was mediated by the L3T4+, Ly-2- T cell population, and the generation of TNC coincided with the appearance of delayed-type hypersensitivity response against MM48 antigen. The administration of an auto-I-Ak reactive T helper cell clone MS202 to normal C3H mice resulted in the facilitation of growth of MM48 tumor due to the induction of T suppressor (Ts) cells. Splenic T cells from animals given this T cell clone inhibited the TNC activity of immunized mice resulting in the escape of MM48 from the TNC effect. The surface phenotype of the Ts cells was L3T4+, Ly-2-. The Ts cells induced by the clone MS202 were totally antigen-nonspecific, and were able to suppress both the effector and inductive processes of TNC. The results suggest the presence of a physiological MHC-restricted T cell circuit that regulates immune responses against the growing tumors.

摘要

用经辐射的同基因MM48肿瘤细胞免疫C3H小鼠可诱导出特异性肿瘤中和细胞（TNC）。TNC活性由L3T4⁺、Ly-2⁻ T细胞群体介导，TNC的产生与针对MM48抗原的迟发型超敏反应的出现相一致。将自身I-Ak反应性T辅助细胞克隆MS202给予正常C3H小鼠，由于诱导了T抑制（Ts）细胞，导致MM48肿瘤生长加速。给予该T细胞克隆的动物的脾T细胞抑制了免疫小鼠的TNC活性，导致MM48逃脱TNC效应。Ts细胞的表面表型为L3T4⁺、Ly-2⁻。克隆MS202诱导的Ts细胞完全是非抗原特异性的，并且能够抑制TNC的效应和诱导过程。结果表明存在一种生理性的MHC限制性T细胞回路，其调节针对生长肿瘤的免疫反应。