Tan A L, Phua V C E
Penang General Hospital, Department of Clinical Oncology and Radiotherapy, Malaysia.
University of Malaya, Faculty of Medicine, Clinical Oncology Unit, Kuala Lumpur, Malaysia.
Med J Malaysia. 2014 Jun;69(3):124-5.
Extravasation with intravenous chemotherapy is a common complication of chemotherapy which carries the risk of devastating complications. This study aims to determine the rate of extravasation with intravenous chemotherapy in a major hospital where chemotherapy is delivered in various departments other than the oncology department.
All patients who underwent intravenous chemotherapy in the oncology department and surgical wards in Penang General hospital from 1st February 2008 till 31st June 2008 were recruited retrospectively for this study to look at the rate of extravasation.
A total of 602 patients underwent intravenous chemotherapy during this period. Fifty patients received chemotherapy in the general surgical ward while another 552 patients received chemotherapy in the oncology department. There were 5 cases of extravasation giving an overall extravasation rate of 0.8% (5/602). however, 4 of these cases occurred in the general surgical ward giving it a rate of 8% (4/50).
The rate of extravasation in our hospital was 0.8%. however, this rate can be significantly increased if it is not done under a specialized unit delivering intravenous chemotherapy on a regular basis. Preventive steps including a standard chemotherapy delivery protocol, staff and patient education must be put in place in all units delivering intravenous chemotherapy.
静脉化疗药物外渗是化疗常见的并发症，可能导致严重后果。本研究旨在确定在一家主要医院中，除肿瘤科外其他多个科室开展静脉化疗时的药物外渗发生率。
回顾性纳入2008年2月1日至2008年6月30日期间在槟城总医院肿瘤科和外科病房接受静脉化疗的所有患者，以观察药物外渗发生率。
在此期间，共有602例患者接受了静脉化疗。其中50例在普通外科病房接受化疗，另外552例在肿瘤科接受化疗。发生了5例药物外渗，总体外渗率为0.8%（5/602）。然而，其中4例发生在普通外科病房，外渗率为8%（4/50）。
我院的药物外渗率为0.8%。然而，如果不是在定期开展静脉化疗的专业科室进行化疗，该比率可能会显著升高。在所有开展静脉化疗的科室，必须采取包括标准化化疗给药方案、对工作人员和患者进行教育等预防措施。
