Okhovat Jean-Phillip, Alavi Afsaneh
University of California Los Angeles, CA, USA.
University of Toronto, Toronto, Ontario, Canada
Int J Low Extrem Wounds. 2015 Sep;14(3):262-7. doi: 10.1177/1534734614554284. Epub 2014 Oct 17.
Lipedema is a disorder of adipose tissue that primarily affects females and is often misdiagnosed as obesity or lymphedema. Relatively few studies have defined the precise pathogenesis, epidemiology, and management strategies for this disorder, yet the need to successfully identify this disorder as a unique entity has important implications for proper treatment. In this review, we sought to review and identify information in the existing literature with respect to the epidemiology, pathogenesis, clinical presentation, differential diagnosis, and management strategies for lipedema. The current literature suggests that lipedema appears to be a clinical entity thought to be related to both genetic factors and fat distribution. While distinct from lymphedema and obesity, there are some existing treatments such as complex decongestive physiotherapy, liposuction, and laser-assisted lipolysis. Management of lipedema is complex and distinct from lymphedema. The role of newer randomized controlled studies to further explore the management of this clinical entity remains promising.
脂肪性水肿是一种主要影响女性的脂肪组织疾病，常被误诊为肥胖症或淋巴水肿。相对较少的研究明确了这种疾病的确切发病机制、流行病学及管理策略，但成功将该疾病识别为一种独特病症对于恰当治疗具有重要意义。在本综述中，我们试图回顾并确定现有文献中关于脂肪性水肿的流行病学、发病机制、临床表现、鉴别诊断及管理策略的信息。当前文献表明，脂肪性水肿似乎是一种被认为与遗传因素和脂肪分布均有关的临床病症。虽然与淋巴水肿和肥胖症不同，但目前存在一些治疗方法，如综合消肿物理治疗、抽脂术和激光辅助脂肪分解术。脂肪性水肿的管理很复杂，且与淋巴水肿不同。开展更新的随机对照研究以进一步探索对这一临床病症的管理，前景依然广阔。
