Hamaty D, Valentine J L, Howard R, Howard C W, Wakefield V, Patten M S
Department of Pharmacology, Oral Roberts University School of Medicine, Tulsa, OK.
J Rheumatol Suppl. 1989 Nov;19:164-8.
During a 5 month, double blind crossover study of the clinical effect of cyclobenzaprine on 7 patients with fibrositis, weekly measurements were done of plasma beta-endorphin (endorphin, prostaglandin E (PGE) and catecholamines). Endorphin levels were normal but varied with tender point tenderness. Mean plasma dopamine and PGE were elevated. Norepinephrine was normal to very high while epinephrine levels were continuously low to normal. We conclude that patients with fibrositis have a neurotransmitter plasma profile like other chronic pain states having stress and increased vasomotor activity with the possible exception of having low circulating epinephrine. This disparity may mark a failure of central nervous system pain modulation in fibrositis.
在一项为期5个月的双盲交叉研究中，对7例纤维炎患者使用环苯扎林进行临床疗效观察，每周测量血浆β-内啡肽（内啡肽、前列腺素E（PGE）和儿茶酚胺）。内啡肽水平正常，但随压痛点压痛情况而变化。血浆多巴胺和PGE平均水平升高。去甲肾上腺素水平正常至极高水平，而肾上腺素水平持续偏低至正常。我们得出结论，纤维炎患者的神经递质血浆谱与其他伴有应激和血管舒缩活动增强的慢性疼痛状态相似，可能的例外是循环肾上腺素水平较低。这种差异可能标志着纤维炎患者中枢神经系统疼痛调节功能的失败。
