Kolodiazhnyi Oleg I
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Str, 1, Kiev, Ukraine,
Top Curr Chem. 2015;360:161-236. doi: 10.1007/128_2014_564.
This chapter points out significant advances in the asymmetric synthesis of P-chiral organophosphorus compounds with many applications in stereoselective synthesis and in asymmetric catalysis, making reference to updated literature findings as well as the author's original research. Asymmetric addition and cycloaddition reactions, oxidation, including metal catalyzed and non-metal biocatalytic methods are described, in addition to synthetic approaches via nucleophilic substitution of appropriately substituted precursors. Use of chiral organophosphorus compounds in some asymmetric transformations such as hydrogenation and alkyl/arylation reactions is also discussed.
本章指出了P-手性有机磷化合物不对称合成方面的重大进展，这些化合物在立体选择性合成和不对称催化中有许多应用，并参考了最新的文献研究结果以及作者的原创研究。文中描述了不对称加成和环加成反应、氧化反应，包括金属催化和非金属生物催化方法，此外还介绍了通过适当取代前体的亲核取代进行的合成方法。还讨论了手性有机磷化合物在一些不对称转化中的应用，如氢化反应和烷基/芳基化反应。
