Semicheva T V
Pediatriia. 1989(11):49-53.
The data are provided on the continuous use of Androcur in the treatment of genuine precocious puberty in children. The drug produced a beneficial effect in 100% of cases in respect to suppression of the secondary sexual characters, menstrual function in girls, and behavior normalization in boys. During treatment, the improvement of the growth prognosis was negligible. Stabilization of the processes of osseous maturation requires administration of the maximal drug doses, which may suppress glucocorticoid function of the adrenals. This fact should be taken into account during treatment, particularly on its discontinuation. The treatment should be discontinued according to the schedule similar to that applied in glucocorticoid discontinuation.
提供了关于安雄持续用于治疗儿童真性性早熟的数据。该药物在抑制第二性征、女孩月经功能以及男孩行为正常化方面，100%的病例产生了有益效果。治疗期间，生长预后的改善可忽略不计。骨成熟过程的稳定需要给予最大药物剂量，这可能会抑制肾上腺的糖皮质激素功能。治疗期间，尤其是停药时，应考虑到这一事实。应按照与停用糖皮质激素相似的时间表停药。
