家猫退行性关节病、疼痛与巴尔通体属血清反应性之间的关系。

Relationship between degenerative joint disease, pain, and Bartonella spp. seroreactivity in domesticated cats.

作者信息

Tomas A, Pultorak E L, Gruen M E, Breitschwerdt E B, Lascelles B D X

机构信息

Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

出版信息

J Vet Intern Med. 2015 Jan;29(1):21-7. doi: 10.1111/jvim.12495. Epub 2014 Oct 18.

DOI:10.1111/jvim.12495

PMID:25327962

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4407694/

Abstract

BACKGROUND

Recently, a potential association was identified between Bartonella exposure and arthritides in mammalian species other than cats.

HYPOTHESIS/OBJECTIVES: We hypothesized that Bartonella exposure is associated with more severe degenerative joint disease (DJD) and a greater burden of DJD-associated pain in client-owned cats.

ANIMALS

Ninety-four client-owned cats (6 months to 20 years old), ranging from clinically unaffected to severely lame because of DJD.

METHODS

Using physical examination and radiography, pain and radiographic scores were assigned to each part of the bony skeleton. Sera were tested for Bartonella henselae, B. koehlerae, and B. vinsonii subsp. berkhoffii (genotypes I, II, and III) antibodies using immunofluorescence antibody assays. Variables were categorized and logistic regression used to explore associations.

RESULTS

Seropositivity to Bartonella was identified in 33 (35.1%) cats. After multivariate analysis controlling for age, total DJD score (OR, 0.51; 95% CI, 0.26-0.97; P = .042), appendicular pain score (OR, 0.33; 95% CI, 0.17-0.65; P = .0011), and total pain score (OR, 0.35; 95% CI, 0.17-0.72; P = .0045) were significantly inversely associated with Bartonella seroreactivity status, indicating that cats with higher DJD and pain scores were less likely to be Bartonella seropositive.

CONCLUSIONS AND CLINICAL IMPORTANCE

Based upon this preliminary study, Bartonella spp. seropositivity was associated with decreased severity of DJD and decreased DJD-associated pain in cats. Additional studies are needed to verify these findings, and if verified, to explore potential mechanisms.

摘要

背景

最近，在猫以外的哺乳动物物种中发现巴尔通体暴露与关节炎之间存在潜在关联。

假设/目标：我们假设巴尔通体暴露与宠物猫更严重的退行性关节疾病（DJD）以及DJD相关疼痛的更大负担有关。

动物

94只宠物猫（6个月至20岁），范围从临床上未受影响到因DJD而严重跛行。

方法

通过体格检查和X线摄影，为骨骼的每个部位分配疼痛和X线评分。使用免疫荧光抗体测定法检测血清中的汉赛巴尔通体、科氏巴尔通体和文森巴尔通体亚种伯克霍夫巴尔通体（基因型I、II和III）抗体。对变量进行分类，并使用逻辑回归来探索关联。

结果

在33只（35.1%）猫中检测到巴尔通体血清阳性。在对年龄进行多变量分析后，总DJD评分（OR，0.51；95%CI，0.26 - 0.97；P = 0.042）、附属肢体疼痛评分（OR，0.33；95%CI，0.17 - 0.65；P = 0.0011）和总疼痛评分（OR，0.35；95%CI，0.17 - 0.72；P = 0.0045）与巴尔通体血清反应性状态显著负相关，表明DJD和疼痛评分较高的猫巴尔通体血清阳性的可能性较小。