Faculty of Life Sciences, Division of Biosciences, University College London, London, UK.
Highcroft Vets, Bristol, UK.
J Feline Med Surg. 2021 Oct;23(10):965-975. doi: 10.1177/1098612X21991456. Epub 2021 Feb 11.
The aim of this case-control study was to identify early-life risk factors associated with the occurrence of owner-reported mobility changes in 6-year-old cats by examining prospective data from a longitudinal cohort study of pet cats, the Bristol Cats study.
Data on potential risk factors were obtained from seven sequential questionnaires completed between the ages of 2-4 months and 5 years. Mobility-related questions from the study questionnaire distributed at the age of 6 years were used to calculate each cat's mobility score. Cats with mobility scores of ⩾2 and 0 were allocated to the case and control groups, respectively, and the cat's status was the outcome variable.
Of the 799 cats included for analysis, 238 (29.8%) had owner-reported mobility changes. Binomial logistic regression using backwards elimination identified four risk factors for owner-reported mobility changes at 6 years of age: entire neuter status at 6 months of age (odds ratio [OR] 1.97; 95% confidence interval [CI] 1.26-3.07), sustained trauma before 6 years of age (OR 1.85; 95% CI 1.30-2.60), outdoor access at 6 years of age (OR 1.67; 95% CI 0.96-2.90) and overweight/obese status at 6 years of age (OR 1.62; 95% CI 1.13-2.33).
Risk factor analysis demonstrated that obesity, outdoor access and a history of trauma may predispose cats to developing owner-reported mobility changes associated with degenerative joint disease, whereas neutering before 6 months of age appears to decrease that risk.
本病例对照研究旨在通过检查宠物猫纵向队列研究——布里斯托猫研究的前瞻性数据，确定与 6 岁猫主人报告的运动变化相关的早期生活风险因素。
通过在 2-4 月龄至 5 岁之间完成的七项连续问卷调查，获取潜在风险因素的数据。使用 6 岁时分发的研究问卷中的与运动相关问题来计算每只猫的运动评分。运动评分 ⩾2 分和 0 分的猫分别被分配到病例组和对照组，猫的状态为结局变量。
在纳入分析的 799 只猫中，有 238 只（29.8%）有主人报告的运动变化。使用向后消除法的二项逻辑回归确定了 6 岁时主人报告的运动变化的四个风险因素：6 月龄时的完全去势状态（优势比[OR]1.97；95%置信区间[CI]1.26-3.07）、6 岁前持续的创伤（OR 1.85；95% CI 1.30-2.60）、6 岁时的户外活动（OR 1.67；95% CI 0.96-2.90）和 6 岁时超重/肥胖状态（OR 1.62；95% CI 1.13-2.33）。
风险因素分析表明，肥胖、户外活动和创伤史可能使猫易发生退行性关节病相关的主人报告的运动变化，而 6 月龄前去势似乎降低了这种风险。
