Lu Guolan, Halig Luma, Wang Dongsheng, Chen Zhuo Georgia, Fei Baowei
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.
Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
Proc SPIE Int Soc Opt Eng. 2014 Mar 21;9034:903413. doi: 10.1117/12.2043796.
As an emerging technology, hyperspectral imaging (HSI) combines both the chemical specificity of spectroscopy and the spatial resolution of imaging, which may provide a non-invasive tool for cancer detection and diagnosis. Early detection of malignant lesions could improve both survival and quality of life of cancer patients. In this paper, we introduce a tensor-based computation and modeling framework for the analysis of hyperspectral images to detect head and neck cancer. The proposed classification method can distinguish between malignant tissue and healthy tissue with an average sensitivity of 96.97% and an average specificity of 91.42% in tumor-bearing mice. The hyperspectral imaging and classification technology has been demonstrated in animal models and can have many potential applications in cancer research and management.
作为一种新兴技术，高光谱成像（HSI）结合了光谱学的化学特异性和成像的空间分辨率，这可能为癌症检测和诊断提供一种非侵入性工具。恶性病变的早期检测可以提高癌症患者的生存率和生活质量。在本文中，我们介绍了一种基于张量的计算和建模框架，用于分析高光谱图像以检测头颈癌。所提出的分类方法在荷瘤小鼠中区分恶性组织和健康组织的平均灵敏度为96.97%，平均特异性为91.42%。高光谱成像和分类技术已在动物模型中得到验证，并且在癌症研究和管理中可能有许多潜在应用。
