Gao H, Tian Y, Meng H, Hou J, Xu L, Zhang L, Shi D, Lu R, Feng X, Wang X, Chen Z
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
J Periodontal Res. 2015 Aug;50(4):509-18. doi: 10.1111/jre.12237. Epub 2014 Oct 20.
Dyslipidemia is associated with aggressive periodontitis, a condition characterized by the rapid destruction of the periodontium. Apolipoprotein E (APOE) and low-density lipoprotein receptor-related protein 5 (LRP5) are involved in immunomodulation and inflammatory activity. We evaluated the association of LRP5 and APOE polymorphisms with serum lipid concentrations and generalized aggressive periodontitis within a Chinese population.
Mean serum lipid concentrations were compared across LRP5 and APOE polymorphisms, among cases (n = 185) and controls (n = 138). Multivariable logistic regression was used to evaluate the independent and combined associations of LRP5 and APOE polymorphisms with generalized aggressive periodontitis.
Compared with controls, individuals with generalized aggressive periodontitis exhibited significantly lower serum total cholesterol (TC) and lower high-density lipoprotein cholesterol (HDL-c). Individuals with LRP5 polymorphisms (rs682429-AA or rs312016-GG) exhibited higher TC, higher HDL-c and decreased odds for generalized aggressive periodontitis. Haplotype (A-G), determined by rs682429 and rs312016, was also associated with decreased odds for generalized aggressive periodontitis. Furthermore, individuals with the combined polymorphisms (LRP5-rs682429-AA and APOE-rs429358-CC/CT) had higher levels of low-density lipoprotein cholesterol, higher levels of TC and decreased odds for generalized aggressive periodontitis.
Independently or combined with APOE, LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.
血脂异常与侵袭性牙周炎相关，侵袭性牙周炎是一种以牙周组织快速破坏为特征的病症。载脂蛋白E（APOE）和低密度脂蛋白受体相关蛋白5（LRP5）参与免疫调节和炎症活动。我们评估了中国人群中LRP5和APOE基因多态性与血脂浓度及广泛性侵袭性牙周炎的关联。
比较了185例病例和138例对照中LRP5和APOE基因多态性的平均血脂浓度。采用多变量逻辑回归评估LRP5和APOE基因多态性与广泛性侵袭性牙周炎的独立及联合关联。
与对照组相比，广泛性侵袭性牙周炎患者的血清总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-c）显著降低。具有LRP5基因多态性（rs682429-AA或rs312016-GG）的个体TC更高、HDL-c更高，且患广泛性侵袭性牙周炎的几率降低。由rs682429和rs312016确定的单倍型（A-G）也与广泛性侵袭性牙周炎的患病几率降低相关。此外，具有联合多态性（LRP5-rs682429-AA和APOE-rs429358-CC/CT）的个体低密度脂蛋白胆固醇水平更高、TC水平更高，患广泛性侵袭性牙周炎的几率降低。
LRP5基因多态性单独或与APOE联合，可能导致血脂异常，并与广泛性侵袭性牙周炎相关。血脂异常可能是中国人群中广泛性侵袭性牙周炎的一个风险指标。此外，两个LRP5基因多态性（rs682429和rs312016）可能有助于识别患广泛性侵袭性牙周炎风险较高的个体。
