Lawson Edwina, Sabin Caroline, Perry Nicky, Richardson Daniel, Gilleece Yvonne, Churchill Duncan, Dean Gillian, Williams Debbie, Fisher Martin, Walker-Bone Karen
St John's Medical Centre.
Research Department of Infection and Population Health, UCL, Royal Free Campus, London.
Clin J Pain. 2015 Sep;31(9):813-819. doi: 10.1097/AJP.0000000000000162.
To evaluate the prevalence, impact, and risk factors for pain among a cohort of human immunodeficiency virus (HIV)-infected adults treated with combination antiretroviral therapy if indicated according to current guidelines.
This was a cross-sectional epidemiological observational study. All patients attending 1 HIV-outpatient center in the United Kingdom in a 10-month period were eligible. Patients completed a validated questionnaire enquiring about demographics, HIV factors, and symptoms of pain.
Of 1050 eligible participants, 859 (82%) completed a questionnaire. The 1-month period prevalence of pain lasting >1 day was 62.8% among whom 63% reported current pain. The prevalence of pain at most anatomic sites was broadly similar to that observed in population studies using the same questionnaires except that we found considerably higher rates of foot/ankle pain. The median duration of pain was 3 years (range, 0 to 51 y) and the median pain score was 5.0 on an 11-point visual analogue score. Over 40% of people in pain had consulted their primary care physician and >20% were taking analgesics daily. Independent risk factors for current pain were older age (P=0.001), time since diagnosis of HIV infection (P=0.001), and receipt of a protease inhibitor-based regimen (P=0.04).
Pain, and notably foot/ankle pain, is common among adults living with prevalent HIV and is associated with substantial morbidity and health care utilization.
根据现行指南，评估一组接受联合抗逆转录病毒治疗的人类免疫缺陷病毒（HIV）感染成人中疼痛的患病率、影响及危险因素。
这是一项横断面流行病学观察性研究。在10个月期间就诊于英国1家HIV门诊中心的所有患者均符合条件。患者完成一份经过验证的问卷，询问人口统计学、HIV相关因素及疼痛症状。
1050名符合条件的参与者中，859名（82%）完成了问卷。持续超过1天的疼痛在1个月期间的患病率为62.8%，其中63%报告目前有疼痛。除了我们发现足部/踝关节疼痛发生率显著更高外，大多数解剖部位的疼痛患病率与使用相同问卷的人群研究中观察到的大致相似。疼痛的中位持续时间为3年（范围0至51年），在11分视觉模拟评分上，疼痛中位评分为5.0。超过40%的疼痛患者咨询过他们的初级保健医生，超过20%的患者每天服用镇痛药。目前疼痛的独立危险因素为年龄较大（P = 0.001）、自诊断HIV感染以来的时间（P = 0.001）以及接受基于蛋白酶抑制剂的治疗方案（P = 0.04）。
疼痛，尤其是足部/踝关节疼痛，在感染HIV的成年人中很常见，并且与相当大的发病率和医疗保健利用相关。
