Chanoine C, Guyot-Lenfant M, d'Albis A, Durand J P, Perasso F, Salles-Mourlan A M, Janmot C, Gallien C L
Laboratoire de Biologie du Développement, UA CNRS 1188, Université René Descartes, Paris, France.
Cell Differ Dev. 1989 Nov;28(2):135-44. doi: 10.1016/0922-3371(89)90050-6.
In the perennibranchiate Proteus anguinus, larval myosin isoforms were shown to coexist for life with the adult isomyosins that appeared at the end of the larval stage. Analysis of the myofibrillar ATPase profile also revealed that a high percentage of immature fibers persisted in adults. A long-term treatment with large amounts of T3 had no effect on juvenile individuals. Applied to subadult animals it promoted a regression of larval myosin isoforms and a reduction in the percentage of immature fiber types. The regulative effect of T3 in the myosin isoenzymic transition may be delayed and depends on metabolic conditions, which suggests it is indirect.
在终生具鳃的洞螈中，幼虫肌球蛋白同工型被证明与在幼虫期末出现的成年同型肌球蛋白终生共存。对肌原纤维ATP酶谱的分析还表明，成年个体中仍有很大比例的未成熟纤维。大量T3的长期处理对幼年个体没有影响。应用于亚成年动物时，它促进了幼虫肌球蛋白同工型的消退，并降低了未成熟纤维类型的百分比。T3在肌球蛋白同工酶转变中的调节作用可能会延迟，并且取决于代谢条件，这表明它是间接的。
