Furui H, Yamada Y, Yamauchi K, Hayashi H, Saito H, Sotobata I
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Clin Ther. 1989 Nov-Dec;11(6):786-94.
Lipid metabolism, platelet function, and blood coagulability were evaluated in 20 patients with diabetes mellitus and stable fasting blood sugar levels before, during, and after treatment with the pancreatic enzyme elastase for 16 weeks. Serum high-density lipoprotein cholesterol levels increased from 46.9 mg/dl before treatment to 53.2 mg/dl after treatment (P less than 0.001) and serum triglyceride levels decreased from 151.4 to 125.4 mg/dl (P less than 0.05); no significant changes in total cholesterol levels were noted. Platelet counts in whole blood and in platelet-rich plasma increased from 17.1 and 27.5 X 10(4)/mm3, respectively, to 19.8 and 31.3 X 10(4)/mm3 after treatment (P less than 0.01 and less than 0.05). Plasma beta-thromboglobulin levels decreased from 117.0 to 72.7 ng/ml after treatment (P less than 0.001). No significant changes in platelet sensitivity to adenosine diphosphate aggregation were noted. Plasma fibrinogen and antithrombin III levels increased from 421.0 and 25.8 mg/dl, respectively, to 470.6 and 32.0 mg/dl after treatment (P less than 0.05 and less than 0.001). It is concluded that, since it has been shown that elastase improved lipid metabolism, inhibited platelet release, and increased antithrombin III levels, it may play a useful role in the prevention of vascular complications in diabetic patients.
对20例糖尿病患者且空腹血糖水平稳定者，在使用胰酶弹性蛋白酶治疗16周之前、治疗期间及治疗之后，对其脂质代谢、血小板功能和血液凝固性进行了评估。血清高密度脂蛋白胆固醇水平从治疗前的46.9mg/dl升至治疗后的53.2mg/dl（P＜0.001），血清甘油三酯水平从151.4mg/dl降至125.4mg/dl（P＜0.05）；总胆固醇水平未见显著变化。全血和富血小板血浆中的血小板计数分别从治疗前的17.1×10⁴/mm³和27.5×10⁴/mm³升至治疗后的19.8×10⁴/mm³和31.3×10⁴/mm³（P＜0.01和＜0.05）。治疗后血浆β-血小板球蛋白水平从117.0ng/ml降至72.7ng/ml（P＜0.001）。血小板对二磷酸腺苷聚集的敏感性未见显著变化。治疗后血浆纤维蛋白原和抗凝血酶III水平分别从421.0mg/dl和25.8mg/dl升至470.6mg/dl和32.0mg/dl（P＜0.05和＜0.001）。结论是，由于已表明弹性蛋白酶可改善脂质代谢、抑制血小板释放并提高抗凝血酶III水平，它可能在预防糖尿病患者血管并发症方面发挥有益作用。
