通过2-氨基芳基丙烯酸酯/2-氨基查尔酮与甲苯磺酰甲基异腈（TosMIC）一锅法合成吡咯并[3,4-c]喹啉酮/吡咯并[3,4-c]喹啉衍生物。
One pot synthesis of pyrrolo[3,4-c]quinolinone/pyrrolo[3,4-c]quinoline derivatives from 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC).
作者信息
Lu Xin-Mou, Li Jian, Cai Zhong-Jian, Wang Rong, Wang Shun-Yi, Ji Shun-Jun
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, People's Republic of China.
出版信息
Org Biomol Chem. 2014 Dec 14;12(46):9471-7. doi: 10.1039/c4ob01580k. Epub 2014 Oct 20.
An efficient and practical synthetic approach to access to 2H-pyrrolo[3,4-c]quinolin-4(5H)-one/2H-pyrrolo[3,4-c]quinoline derivatives by the reaction of 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC) via a one pot van Leusen reaction and cyclization under basic conditions has been reported. The desired products could be obtained in moderate to good yields.
据报道，通过2-氨基芳基丙烯酸酯/2-氨基查耳酮与甲苯磺酰甲基异腈（TosMIC）经一锅法范鲁森反应并在碱性条件下环化，可得到一种高效实用的合成方法来制备2H-吡咯并[3,4-c]喹啉-4(5H)-酮/2H-吡咯并[3,4-c]喹啉衍生物。所需产物能够以中等至良好的产率获得。
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