2-溴甲基唑与TosMIC的反应：生成氮杂环嘧啶的多米诺过程。痘病毒素生物碱核心三环的合成。
Reaction of 2-bromomethylazoles and TosMIC: A domino process to azolopyrimidines. Synthesis of core tricycle of the variolins alkaloids.
作者信息
Mendiola J, Minguez J M, Alvarez-Builla J, Vaquero J J
机构信息
Departamento de Química Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
出版信息
Org Lett. 2000 Oct 19;2(21):3253-6. doi: 10.1021/ol0062087.
PMID:11029183
Abstract
A new reaction of N-protected 2-bromomethylazoles and tosylmethyl isocyanide (TosMIC) leading to the preparation of azolopyrimidines is described. This domino sequence was used to synthesize the pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine core of alkaloids variolins from 4-methoxy-2-methylpyrrolo[2,3-b]pyrimidine in two steps.
摘要
描述了一种N-保护的2-溴甲基唑与甲苯磺酰甲基异腈（TosMIC）生成氮杂环嘧啶的新反应。该多米诺反应序列用于从4-甲氧基-2-甲基吡咯并[2,3-b]嘧啶分两步合成生物碱变叶木素的吡啶并[3',2':4,5]吡咯并[1,2-c]嘧啶核心。
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