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1
Antibody affinity maturation: the role of CD8+ cells.抗体亲和力成熟：CD8 + 细胞的作用。
Clin Exp Immunol. 1989 Dec;78(3):488-93.
2
Antibody affinity maturation in selectively bred high and low-affinity mice.选择性培育的高亲和力和低亲和力小鼠中的抗体亲和力成熟
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Experimental zinc deficiency: effects on cellular responses and the affinity of humoral antibody.实验性锌缺乏：对细胞反应和体液抗体亲和力的影响
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4
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Eur J Immunol. 1988 Apr;18(4):495-502. doi: 10.1002/eji.1830180402.
5
Characterization of anti-CD8-resistant cytolytic T lymphocytes induced by multivalent cross-linking of CD8 on precursor cells.前体细胞上CD8多价交联诱导的抗CD8抗性细胞溶解T淋巴细胞的特性分析
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Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.小鼠上皮内淋巴细胞的调节功能。CD3+、T细胞受体-1+上皮内淋巴细胞T细胞的两个亚群可消除口服耐受性。
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The in vivo elimination of CD4+ T cells prevents the induction but not the expression of carrier-induced epitopic suppression.体内清除CD4+ T细胞可阻止载体诱导的表位抑制的诱导，但不能阻止其表达。
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8
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引用本文的文献

1
Low antibody affinity restricted to the IgA isotype in IgA nephropathy.IgA肾病中低抗体亲和力仅限于IgA同种型。
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2
The affinity of IgG antibodies to gag p24 and p17 in HIV-1-infected patients correlates with disease progression.在HIV-1感染患者中，IgG抗体对gag p24和p17的亲和力与疾病进展相关。
Clin Exp Immunol. 1995 Feb;99(2):175-81. doi: 10.1111/j.1365-2249.1995.tb05529.x.
3
Interferon-gamma potentiates antibody affinity in mice with a genetically controlled defect in affinity maturation.在亲和力成熟存在基因控制缺陷的小鼠中，γ干扰素可增强抗体亲和力。
Clin Exp Immunol. 1990 Nov;82(2):221-6. doi: 10.1111/j.1365-2249.1990.tb05430.x.
4
High-affinity antibody induced by immunization with a synthetic peptide is associated with protection of cattle against foot-and-mouth disease.用合成肽免疫诱导产生的高亲和力抗体与牛对口蹄疫的保护作用相关。
Immunology. 1991 Jan;72(1):99-103.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The adjuvant activity of nonionic block polymer surfactants. I. The role of hydrophile-lipophile balance.非离子嵌段聚合物表面活性剂的佐剂活性。I. 亲水亲油平衡的作用。
J Immunol. 1981 Sep;127(3):1244-50.
3
The measurement of antibody affinity: a comparison of five techniques utilizing a panel of monoclonal anti-DNP antibodies and the effect of high affinity antibody on the measurement of low affinity antibody.抗体亲和力的测定：使用一组抗二硝基苯酚单克隆抗体对五种技术的比较以及高亲和力抗体对低亲和力抗体测定的影响
J Immunol Methods. 1983 Nov 11;64(1-2):119-32. doi: 10.1016/0022-1759(83)90390-3.
4
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone.体细胞突变与对2-苯基恶唑酮免疫反应的成熟
Nature. 1984;312(5991):271-5. doi: 10.1038/312271a0.
5
Suppressor cells and the handling of antigen.抑制细胞与抗原处理
Immunol Rev. 1980;50:3-45. doi: 10.1111/j.1600-065x.1980.tb00306.x.
6
Failure of affinity maturation leads to increased susceptibility to immune complex glomerulonephritis.亲和力成熟的失败会导致对免疫复合物性肾小球肾炎的易感性增加。
Immunology. 1984 Jun;52(2):377-83.
7
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.通过体内消除T细胞亚群进行单克隆抗体治疗。
Nature. 1984;312(5994):548-51. doi: 10.1038/312548a0.
8
Cell selection by antigen in the immune response.免疫应答中抗原介导的细胞选择。
Adv Immunol. 1969;10:1-50. doi: 10.1016/s0065-2776(08)60414-9.
9
Selective roles of thymus-derived lymphocytes in the antibody response. II. Preferential suppression of high-affinity antibody-forming cells by carrier-primed suppressor T cells.胸腺来源淋巴细胞在抗体应答中的选择性作用。II. 载体致敏抑制性T细胞对高亲和力抗体形成细胞的优先抑制作用。
J Exp Med. 1974 Jul 1;140(1):253-66. doi: 10.1084/jem.140.1.253.
10
Immuno-regulatory role of spleen localizing thymocytes.脾脏定位胸腺细胞的免疫调节作用。
J Immunol. 1974 Feb;112(2):546-54.

抗体亲和力成熟：CD8 + 细胞的作用。

Antibody affinity maturation: the role of CD8+ cells.

作者信息

Holland G P, Steward M W

机构信息

Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, England.

出版信息

Clin Exp Immunol. 1989 Dec;78(3):488-93.

PMID:2532994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534833/
Abstract

The cellular control of antibody affinity maturation has been studied in mice genetically selected for their failure to demonstrate an increase in affinity following immunization (low-affinity N/M mice). Depletion of CD8+ cells in low N/M mice by thymectomy and/or anti-CD8 antibody treatment resulted in these animals acquiring the ability to mount an anti-DNP response of progressively increasing affinity. This indicates that CD8+ cells play an important regulatory role in the cellular interactions underlying the process of affinity maturation. In addition, evidence is presented which suggests that the route of immunization may also be critical in determining the affinity of antibody produced.

摘要

对那些经基因筛选、免疫后无法表现出亲和力增加的小鼠（低亲和力N/M小鼠）进行了抗体亲和力成熟的细胞调控研究。通过胸腺切除和/或抗CD8抗体处理耗尽低N/M小鼠中的CD8 +细胞，导致这些动物获得了产生亲和力逐渐增加的抗DNP反应的能力。这表明CD8 +细胞在亲和力成熟过程所涉及的细胞相互作用中起重要的调节作用。此外，有证据表明免疫途径在决定所产生抗体的亲和力方面也可能至关重要。