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抗体亲和力成熟：CD8 + 细胞的作用。

Antibody affinity maturation: the role of CD8+ cells.

作者信息

Holland G P, Steward M W

机构信息

Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, England.

出版信息

Clin Exp Immunol. 1989 Dec;78(3):488-93.

PMID:2532994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534833/
Abstract

The cellular control of antibody affinity maturation has been studied in mice genetically selected for their failure to demonstrate an increase in affinity following immunization (low-affinity N/M mice). Depletion of CD8+ cells in low N/M mice by thymectomy and/or anti-CD8 antibody treatment resulted in these animals acquiring the ability to mount an anti-DNP response of progressively increasing affinity. This indicates that CD8+ cells play an important regulatory role in the cellular interactions underlying the process of affinity maturation. In addition, evidence is presented which suggests that the route of immunization may also be critical in determining the affinity of antibody produced.

摘要

对那些经基因筛选、免疫后无法表现出亲和力增加的小鼠（低亲和力N/M小鼠）进行了抗体亲和力成熟的细胞调控研究。通过胸腺切除和/或抗CD8抗体处理耗尽低N/M小鼠中的CD8 +细胞，导致这些动物获得了产生亲和力逐渐增加的抗DNP反应的能力。这表明CD8 +细胞在亲和力成熟过程所涉及的细胞相互作用中起重要的调节作用。此外，有证据表明免疫途径在决定所产生抗体的亲和力方面也可能至关重要。

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