Donnez J, Nisolle M
Baillieres Clin Obstet Gynaecol. 1989 Sep;3(3):525-43. doi: 10.1016/s0950-3552(89)80007-0.
Used endoscopically, the CO2 laser offers some advantages over other operative techniques for endometriosis and adhesions but, in spite of the continuing development of new instrumentation there are still problems with the system. The technique needs specialized equipment requiring ongoing biomedical maintenance and specialized technical care in the operating room. Some problems such as the intraperitoneal accumulation of smoke, gas leakage, and difficulty with maintenance of proper beam alignment still occur. In spite of these problems the advantages are numerous: the system allows precise bloodless destruction of diseased tissue and eliminates the risks of cautery. In the hands of an experienced laparoscopist, it appears safe and effective in vaporization of endometriotic lesions, utero-sacral neurectomy, adhesiolysis and salpingostomy. The judicious use of these techniques, combined with carefully planned further investigations by well-trained and experienced laparoscopists and continuing improvements in the delivery systems, will soon reveal the true efficacy of the CO2 laser laparoscope. If studies continue to show pregnancy rates and pain relief to be equivalent to those patients treated by laparotomy, CO2 laser laparoscopy will become the preferred procedure for the management of pelvic endometriosis and its associated adhesions, distal tubal occlusion, pelvic pain and tubal pregnancy. With the exception of using the argon laser to treat endometriosis, the selective absorption characteristic of lasers has not been greatly utilized. While the CO2 laser is heavily absorbed by water and hence vaporizes most cells in a rather indiscriminate fashion, this is not true for other wavelengths, such as argon, Nd-YAG, KTP, krypton, xenon, copper and gold vapour lasers. The energy form of each of these lasers has different properties of penetration, absorption, reflection and heat dissipation. Many of these lasers have not yet been evaluated in human subjects. An exciting, although not new, area of possible laser application involves the use of photosensitizers and fluorescing agents (Dougherty et al, 1978). Some recent experimental studies (Schellhas and Schneider, 1986; Schneider et al, 1988) may lead to new therapeutic possibilities. The surgical laser is not, however, a panacea. Only controlled trials carried out carefully over the next few years will clearly define its potential. In the meantime it is incumbent upon all of us to investigate the clinical, gynaecological and surgical applications in a careful, methodical and scientific manner.
在内窥镜检查中使用时,二氧化碳激光与其他用于治疗子宫内膜异位症和粘连的手术技术相比具有一些优势,但尽管新仪器不断发展,该系统仍存在问题。该技术需要专门的设备,需要持续的生物医学维护以及手术室中的专业技术护理。仍然会出现一些问题,例如腹腔内烟雾积聚、气体泄漏以及难以保持光束正确对准。尽管存在这些问题,但优势众多:该系统能够精确地无血破坏病变组织,并消除烧灼的风险。在经验丰富的腹腔镜医师手中,它在汽化子宫内膜异位症病变、子宫骶骨神经切除术、粘连松解术和输卵管造口术方面似乎是安全有效的。明智地使用这些技术,结合训练有素且经验丰富的腹腔镜医师精心规划的进一步研究以及输送系统的不断改进,很快将揭示二氧化碳激光腹腔镜的真正疗效。如果研究继续表明妊娠率和疼痛缓解情况与剖腹手术治疗的患者相当,二氧化碳激光腹腔镜检查将成为治疗盆腔子宫内膜异位症及其相关粘连、远端输卵管阻塞、盆腔疼痛和输卵管妊娠的首选方法。除了使用氩激光治疗子宫内膜异位症外,激光的选择性吸收特性尚未得到充分利用。虽然二氧化碳激光被水大量吸收,因此以相当随意的方式汽化大多数细胞,但其他波长的激光并非如此,例如氩、钕 - 钇铝石榴石、磷酸钛氧钾、氪、氙、铜和金蒸汽激光。这些激光中的每一种的能量形式都具有不同的穿透、吸收、反射和散热特性。其中许多激光尚未在人体受试者中进行评估。一个令人兴奋的、虽不新鲜但可能的激光应用领域涉及使用光敏剂和荧光剂(多尔蒂等人,1978年)。一些近期的实验研究(谢尔哈斯和施耐德,1986年;施耐德等人,1988年)可能会带来新的治疗可能性。然而,手术激光并非万灵药。只有在未来几年仔细进行的对照试验才能明确其潜力。与此同时,我们所有人都有责任以认真、有条理和科学的方式研究其临床、妇科和外科应用。