Ross Christopher, De Rosa Nicholas, Marshman Gillian, Astill David
Department of Dermatology, Flinders Medical Centre, Adelaide, South Australia, Australia.
Department of Surgical Pathology, Flinders Medical Centre, Adelaide, South Australia, Australia.
Australas J Dermatol. 2015 Aug;56(3):e59-62. doi: 10.1111/ajd.12176. Epub 2014 Oct 21.
A 52-year old woman with chronic renal failure presented with tender buttock nodules, bilateral non-tender periocular papules and yellow scleral plaques. The patient then developed sclerodermoid changes of the hands, as well as woody induration, oedema and hyperpigmentation of lower limbs. There was no previous exposure to gadolinium contrast. Her histology and clinical features were consistent with nephrogenic systemic fibrosis. Treatment with oral sirolimus resulted in a marked reduction of induration and oedema, and an improvement in distal upper limb and lower limb joint mobility.
一名52岁的慢性肾衰竭女性出现臀部压痛性结节、双侧眼周无压痛性丘疹和巩膜黄斑。随后，患者手部出现硬皮病样改变，下肢出现木样硬结、水肿和色素沉着。患者既往未接触过钆造影剂。其组织学和临床特征符合肾源性系统性纤维化。口服西罗莫司治疗后，硬结和水肿明显减轻，上肢远端和下肢关节活动度改善。
