十种非甾体抗炎药（NSAIDs）对某些线粒体和血小板功能影响的比较研究。

A comparative study of the effect of ten non-steroidal anti-inflammatory drugs (NSAIDs) upon some mitochondrial and platelet functions.

Baños G, Reyes P A

Departamento de Bioquimica, Instituto Nacional de Cardiologia Ignacio Chavez, México, D.F. México.

Int J Biochem. 1989;21(12):1387-94. doi: 10.1016/0020-711x(89)90161-4.

Abstract

Ten different NSAIDs were used in a comparative study of their effects upon rat liver mitochondrial and human platelet functions. 2. The drugs behaved like uncouplers of mitochondrial respiration, decreased membrane potential, stimulated ATPase activity and had an ionophore-like effect upon calcium transport. 3. In vitro experiments showed the same effect with 45Ca as well as 22Na. 4. In platelets, aggregation was considerably reduced by most NSAIDs. 5. Addition of ADP (mitochondrial calcium uptake) or magnesium (platelet aggregation and in vitro cation transference) contributed to protect from those effects.

摘要

在一项关于十种不同非甾体抗炎药（NSAIDs）对大鼠肝脏线粒体和人血小板功能影响的比较研究中使用了这些药物。2. 这些药物表现得像线粒体呼吸的解偶联剂，降低膜电位，刺激ATP酶活性，并对钙转运有离子载体样作用。3. 体外实验表明，45Ca和22Na也有相同的效果。4. 在血小板中，大多数NSAIDs可显著降低聚集。5. 添加ADP（线粒体钙摄取）或镁（血小板聚集和体外阳离子转移）有助于防止这些影响。