Talea L
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Ser Oftalmol. 1989 Oct-Dec;33(4):299-303.
The patient, aged 44, presented fever and chills with altered general condition and received an analgesic-antipyretic treatment with salicylic acid and pyrazolon derivatives. A bullous eruption that followed was labelled incipient Lyell syndrome. Both cornea presented ulcers with a tendency to perforation and mucosynechial conjunctivitis. Pathogenic Staphylococcus albus was isolated from the conjunctival secretion. The ocular phenomena improved under mydriatic treatment and trophic medication. Lyell's syndrome is the result of a severe medicamentous toxemia. Stress is laid on the role of Staphylococcus aureus, phage type 71, in the process of epidermal necrosis with detachment of the epithelium and ulceration of the mucosa.
该患者44岁，出现发热、寒战，全身状况改变，接受了水杨酸和吡唑酮衍生物的解热镇痛治疗。随后出现的大疱性皮疹被诊断为早期Lyell综合征。双眼角膜均出现溃疡，有穿孔倾向，并伴有黏膜粘连性结膜炎。从结膜分泌物中分离出致病性白色葡萄球菌。在散瞳治疗和营养药物治疗下，眼部症状有所改善。Lyell综合征是严重药物性毒血症的结果。强调了71型金黄色葡萄球菌在表皮坏死、上皮脱落和黏膜溃疡过程中的作用。
