Isung J, Aeinehband S, Mobarrez F, Nordström P, Runeson B, Asberg M, Piehl F, Jokinen J
Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Transl Psychiatry. 2014 Oct 21;4(10):e470. doi: 10.1038/tp.2014.113.
The dysregulation of inflammation has been associated with depression and, more recently, with suicidal behaviors. The reports regarding the relationship between interleukin-6 (IL-6) and suicide attempts are inconsistent. Personality traits such as impulsivity and aggression are considered endophenotypes and important factors that underlie suicidal behaviors. The aim of the current study was to assess whether plasma and cerebrospinal fluid (CSF) levels of IL-6 are associated with personality traits among suicide attempters. We assessed the relationships among personality traits, IL-6 and violent suicide attempts. The plasma and CSF levels of IL-6 were measured in suicide attempters (plasma=58, CSF=39) using antibody-based immunoassay systems. Personality domains were assessed using the Karolinska Scale of Personality (KSP). IL-6 levels in plasma and CSF were used to predict personality domains via regression models. Plasma IL-6 was significantly and positively correlated with extraversion as well as the KSP subscales impulsivity and monotony avoidance. CSF IL-6 was positively correlated with monotony avoidance. Violent suicide attempts tended to be associated with high plasma IL-6 levels. Plasma and CSF levels of IL-6 were not significantly associated with each other. These results indicate that impulsivity and the choice of a violent suicide attempt method might be related to higher levels of IL-6 in individuals who attempt suicide. The neuroinflammation hypothesis of suicidal behavior on the basis of elevated IL-6 levels might be partly explained by the positive association between IL-6 and impulsivity, which is a key element of the suicidal phenotype.
炎症调节异常与抑郁症相关，最近还与自杀行为有关。关于白细胞介素-6（IL-6）与自杀未遂之间关系的报道并不一致。冲动性和攻击性等人格特质被认为是自杀行为潜在的内表型和重要因素。本研究的目的是评估自杀未遂者的血浆和脑脊液（CSF）中IL-6水平是否与人格特质相关。我们评估了人格特质、IL-6与暴力自杀未遂之间的关系。使用基于抗体的免疫分析系统测量了自杀未遂者（血浆样本58例，脑脊液样本39例）的血浆和脑脊液中IL-6水平。使用卡罗林斯卡人格量表（KSP）评估人格领域。通过回归模型用血浆和脑脊液中的IL-6水平预测人格领域。血浆IL-6与外向性以及KSP分量表冲动性和避免单调显著正相关。脑脊液IL-6与避免单调正相关。暴力自杀未遂往往与高血浆IL-6水平相关。血浆和脑脊液中的IL-6水平彼此之间无显著相关性。这些结果表明，冲动性以及暴力自杀未遂方法的选择可能与自杀未遂者体内较高水平的IL-6有关。基于IL-6水平升高的自杀行为神经炎症假说可能部分由IL-6与冲动性之间的正相关来解释，冲动性是自杀表型的关键要素。
