异丙肾上腺素治疗后唾液腺中的早期基因表达。
Early gene expression in salivary gland after isoproterenol treatment.
作者信息
Zhou Yi, Chen Hung-I H, Lin A L, Dang H, Haack Karin, Cole Shelley A, Huang Yufei, Yu Haiyang, Chen Yidong, Yeh Chih-Ko
机构信息
Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, 78229, Texas; Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, 310000, China.
出版信息
J Cell Biochem. 2015 Mar;116(3):431-7. doi: 10.1002/jcb.24995.
Isoproterenol, a β-adrenergic agonist, has been shown to induce salivary gland hyperplasia. However, the mechanism involved in this pharmacological phenomenon is not well understood. To gain a better understanding of the underlying changes, including genes, networks and pathways altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 min after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. Pathway analysis showed that cell hyperplasia, p38(MAPK), and IGF-1 were the most altered function, network and pathway, respectively. The balanced regulation of up- and down-expression of genes related to cell proliferation/survival may provide a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement without tumor transformation.
异丙肾上腺素是一种β-肾上腺素能激动剂，已被证明可诱导唾液腺增生。然而，这种药理现象所涉及的机制尚未完全明确。为了更好地了解潜在的变化，包括异丙肾上腺素改变的基因、网络和信号通路，在注射异丙肾上腺素后10分钟、30分钟和60分钟，对大鼠腮腺进行了基于微阵列的基因表达分析。异丙肾上腺素处理后，差异表达基因的数量呈时间依赖性增加。通路分析表明，细胞增生、p38（丝裂原活化蛋白激酶）和胰岛素样生长因子-1分别是功能、网络和信号通路改变最为显著的方面。与细胞增殖/存活相关基因的上调和下调表达的平衡调控，可能有助于更好地理解异丙肾上腺素诱导腮腺肿大而不发生肿瘤转化的机制。
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