ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane.

作者信息

Awasthi Y C, Singh S V, Ahmad H, Wronski L W, Srivastava S K, LaBelle E F

机构信息

Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.

出版信息

Mol Cell Biochem. 1989;91(1-2):131-6. doi: 10.1007/BF00228088.

We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione-xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.