Lafata Kyle J, Bushe Harry, Aronowitz Jesse N
Duke University, Durham, NC.
Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA, USA.
J Contemp Brachytherapy. 2014 Oct;6(3):293-6. doi: 10.5114/jcb.2014.45582. Epub 2014 Sep 23.
Nomograms once had a vital role in prostate brachytherapy practice. Although some of their functions have been assumed by computerized dosimetry, many programs still find them useful to determine the number and strength of seeds to be ordered in advance of the implant. As it has been demonstrated that brachytherapists differ in their implant practices and preferences (in regard to seed distribution and total implanted activity), we propose a simple technique for generating institution-specific nomograms.
Using the data generated by previous implants, we demonstrate a simple technique, utilizing ubiquitous software, for generating nomograms to predict seed number, strength, and total implant activity.
Despite wide variations in the degree of post-implant swelling (+12% to +56%), nine of the first ten implants using the generated nomogram have met all target dose parameters.
It is appropriate for each institution to develop nomograms specific to their prostate brachytherapy technique and constraints. Nomograms can estimate the number and strength of seeds to be ordered, and may partially compensate for the effects of implant-induced swelling.
列线图曾在前列腺近距离放射治疗实践中发挥重要作用。尽管其一些功能已被计算机剂量测定法所取代，但许多程序仍发现它们有助于在植入前确定所需种子源的数量和强度。鉴于已有研究表明近距离放射治疗师在植入操作和偏好（种子源分布和总植入活度方面）存在差异，我们提出一种生成特定机构列线图的简单技术。
利用先前植入产生的数据，我们展示了一种使用通用软件生成列线图以预测种子源数量、强度和总植入活度的简单技术。
尽管植入后肿胀程度差异很大（+12%至+56%），但使用生成的列线图进行的前十例植入中有九例达到了所有靶剂量参数。
各机构针对其前列腺近距离放射治疗技术和限制条件开发特定的列线图是合适的。列线图可估计所需订购的种子源数量和强度，并可能部分补偿植入引起的肿胀影响。
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