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Is there a role for anterior zone sampling as part of saturation trans-rectal ultrasound guided prostate biopsy?前区取样在饱和经直肠超声引导前列腺活检中是否有作用？
BMC Urol. 2014 May 3;14:34. doi: 10.1186/1471-2490-14-34.
2
Longitudinal trends in prostate cancer incidence, mortality, and survival of patients from two Shanghai city districts: a retrospective population-based cohort study, 2000-2009.上海市两个城区前列腺癌患者的发病率、死亡率及生存率的纵向趋势：一项基于人群的回顾性队列研究，2000 - 2009年
BMC Public Health. 2014 Apr 14;14:356. doi: 10.1186/1471-2458-14-356.
3
Percent free prostate-specific antigen does not improve the effectiveness of prostate cancer detection in Chinese men with a prostate-specific antigen of 2.5-20.0 ng/ml: a multicenter study.游离前列腺特异性抗原百分比并不能提高前列腺特异性抗原水平在2.5至20.0 ng/ml之间的中国男性前列腺癌检测的有效性：一项多中心研究。
Med Oncol. 2014 Apr;31(4):925. doi: 10.1007/s12032-014-0925-4. Epub 2014 Mar 23.
4
Management of men with a suspicion of prostate cancer after negative initial prostate biopsy results.
Urol Int. 2014;92(3):258-63. doi: 10.1159/000355355. Epub 2014 Mar 12.
5
Free to total serum prostate specific antigen ratio in symptomatic men does not help in differentiating benign from malignant disease of the prostate.有症状男性的血清游离前列腺特异性抗原与总前列腺特异性抗原比值无助于区分前列腺良性疾病与恶性疾病。
Indian J Urol. 2014 Jan;30(1):28-32. doi: 10.4103/0970-1591.124202.
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Cancer statistics, 2014.癌症统计数据，2014 年。
CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29. doi: 10.3322/caac.21208. Epub 2014 Jan 7.
7
Infective complications after prostate biopsy: outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, a prospective multinational multicentre prostate biopsy study.前列腺活检后的感染性并发症：2010 年和 2011 年全球泌尿外科感染研究（GPIU）的结果，一项前瞻性的多国家多中心前列腺活检研究。
Eur Urol. 2013 Mar;63(3):521-7. doi: 10.1016/j.eururo.2012.06.003. Epub 2012 Jun 12.
8
Prospective evaluation of an extended 21-core biopsy scheme as initial prostate cancer diagnostic strategy.前瞻性评估一种扩展的 21 芯活检方案作为初始前列腺癌诊断策略。
Eur Urol. 2014 Jan;65(1):154-61. doi: 10.1016/j.eururo.2012.05.049. Epub 2012 Jun 9.
9
Active surveillance for prostate cancer: a systematic review of the literature.前列腺癌的主动监测：文献系统评价。
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10
Hemospermia after transrectal ultrasound (TRUS)-guided prostatic biopsy: a prospective study.经直肠超声（TRUS）引导下前列腺穿刺活检后血精症：一项前瞻性研究。
J Egypt Soc Parasitol. 2012 Apr;42(1):63-70. doi: 10.12816/0006295.

前列腺特异性抗原与前列腺外腺体积的比值作为前列腺癌的预测指标。

Ratio of prostate specific antigen to the outer gland volume of prostrate as a predictor for prostate cancer.

作者信息

Zhang Hai-Min, Yan Yang, Wang Fang, Gu Wen-Yu, Hu Guang-Hui, Zheng Jun-Hua

机构信息

Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.

出版信息

Int J Clin Exp Pathol. 2014 Aug 15;7(9):6079-84. eCollection 2014.

PMID:25337254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4203225/
Abstract

OBJECTIVE

As a definite diagnosis of prostate cancer, puncture biopsy of the prostate is invasive method. The aim of this study was to evaluate the value of OPSAD (the ratio of PSA to the outer gland volume of prostate) as a non-invasive screening and diagnosis method for prostate cancer in a select population.

METHODS

The diagnosis data of 490 subjects undergoing ultrasound-guided biopsy of the prostate were retrospectively analyzed. This included 133 patients with prostate cancer, and 357 patients with benign prostate hyperplasia (BPH).

RESULTS

The OPSAD was significantly greater in patients with prostate cancer (1.87 ± 1.26 ng/ml(2)) than those with BPH (0.44 ± 0.21 ng/ml(2)) (P < 0.05). Receiver operating characteristic (ROC) curve analysis revealed that the performance of OPSAD as a diagnostic tool is superior to PSA and PSAD for the diagnosis of prostate cancer. In the different groups divided according to the Gleason score of prostate cancer, OPSAD is elevated with the rise of the Gleason score.

CONCLUSION

OPSAD may be used as a new indicator for the diagnosis and prognosis of prostate cancer, and it can reduce the use of unnecessary puncture biopsy of the prostate.

摘要

目的

前列腺穿刺活检是确诊前列腺癌的侵入性方法。本研究旨在评估OPSAD（前列腺特异抗原与前列腺外腺体积之比）作为特定人群前列腺癌非侵入性筛查和诊断方法的价值。

方法

回顾性分析490例接受超声引导下前列腺穿刺活检患者的诊断数据。其中包括133例前列腺癌患者和357例良性前列腺增生（BPH）患者。

结果

前列腺癌患者的OPSAD（1.87±1.26 ng/ml(2)）显著高于BPH患者（0.44±0.21 ng/ml(2)）（P<0.05）。受试者工作特征（ROC）曲线分析显示，OPSAD作为诊断工具在诊断前列腺癌方面的性能优于前列腺特异抗原（PSA）和前列腺特异抗原密度（PSAD）。在根据前列腺癌Gleason评分划分的不同组中，OPSAD随Gleason评分升高而升高。

结论

OPSAD可作为前列腺癌诊断和预后的新指标，并可减少不必要的前列腺穿刺活检的使用。