Yang Fang, Liu Tengfei, Zhao Haiyan, Hu Zhiyan, Xiao Liwei, Liu Yanping, Wang Xiaoyan, Li Zuguo
Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
Department of Pathology, The Central Hospital of Longgang Shenzhen, China.
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6350-6. eCollection 2014.
T-lymphoblastic lymphoma (T-LBP) is a high-grade malignant lymphoma, which possesses the characteristic of high metastasis and high mortality without treatment. We are presenting a special T-lymphoblastic proliferation involving in the oropharynx, nasopharynx, sinus and trachea in a patient with local involved about 15-years without systemic dissemination. The immunophenotype of this case was similar to T-LBP. The proliferous cells were positive for terminal deoxynucleotidyl transferase (TdT), CD3, and appeared co-expression CD4 and CD8. No clonal rearrangements of TCRγ and/or TCRβ gene were detected. Indolent T-lymphoblastic proliferations rarely occurred or unusually could not be diagnosed, combing with the relevant literature and clinically indolent manifestation, we interpreted this case as indolent T-lymphoblastic proliferation (iT-LBPs). So far, the mechanism of the T-lymphoblastic proliferations is still uncertain and requires further study.
T淋巴细胞母细胞淋巴瘤（T-LBP）是一种高度恶性的淋巴瘤，具有未经治疗时高转移和高死亡率的特点。我们报告了1例特殊的T淋巴细胞母细胞增殖病例，累及口咽、鼻咽、鼻窦和气管，局部受累约15年，无全身播散。该病例的免疫表型与T-LBP相似。增殖细胞末端脱氧核苷酸转移酶（TdT）、CD3呈阳性，且出现CD4和CD8共表达。未检测到TCRγ和/或TCRβ基因的克隆重排。惰性T淋巴细胞母细胞增殖很少发生或难以诊断，结合相关文献及临床表现，我们将该病例解释为惰性T淋巴细胞母细胞增殖（iT-LBPs）。目前，T淋巴细胞母细胞增殖的机制仍不明确，需要进一步研究。
