Li Xiang, Liao Wei-Hua, Zhou Jian-Hua, Liu Bao-An, Wen Ji-Fang, Hu Zhong-Liang
Department of Pathology, Xiangya Hospital, Central South University Changsha, China ; Department of Pathology, Xiangya Medical School, Central South University Changsha, China.
Department of Radiology, Xiangya Hospital, Central South University Changsha, China.
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6399-402. eCollection 2014.
Extranodal natural killer (NK)/T-cell lymphoma is a very aggressive malignant neoplasia with a poor prognosis. Herein we reported a case of NK/T cell lymphoma involving mediastinum. It was a 28-year-old Chinese male patient. The tumor cells were medium-sized, had irregularly folded nuclei, and inconspicuous or small nucleoli with coagulative necrosis. The tumor cells were positive for CD3ε, TIA-1, but negative for CD56. In situ hybridization revealed that tumor cells also expressed Epstein-Barr virus encoded RNA. To our knowledge, this is the first case of NK/T cell lymphoma involving mediastinum.
结外自然杀伤（NK）/T细胞淋巴瘤是一种侵袭性很强的恶性肿瘤，预后较差。在此我们报告一例累及纵隔的NK/T细胞淋巴瘤病例。患者为一名28岁的中国男性。肿瘤细胞中等大小，核呈不规则折叠，核仁不明显或较小，伴有凝固性坏死。肿瘤细胞CD3ε、TIA-1呈阳性，但CD56呈阴性。原位杂交显示肿瘤细胞也表达爱泼斯坦-巴尔病毒编码的RNA。据我们所知，这是首例累及纵隔的NK/T细胞淋巴瘤病例。
