Mehrabi Soraya, Eftekhari Sanaz, Moradi Fateme, Delaviz Hamdollah, Pourheidar Bagher, Azizi Monir, Zendehdel Adib, Shahbazi Ali, Joghataei Mohammad Taghi
Division of Neuroscience, Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran.
Division of Neuroscience, Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Basic Clin Neurosci. 2013 Spring;4(2):172-6.
Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provide a suitable microenvironment for axons to regenerate. Here, we reviewed the last approaches applied by our colleagues and others in order to improve axonal regeneration following SCI. We used different types of stem cells via different methods. First, fetal olfactory mucosa, schwann, and bone marrow stromal cells were transplanted into the injury sites in SCI models. In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles. Using these approaches, considerable functional recovery was observed. However, considering some challenges in stem cell therapy such as rejection, infection, and development of a new cancer, our more recent strategy was application of cytokines. We observed a significant improvement in motor function of rats when stromal derived factor-1 was used to attract innate stem cells to the injury site. In conclusion, it seems that co-transplantation of different cells accompanies with other factors like enzymes and growth factors via new delivery systems may yield better results in SCI.
脊髓损伤（SCI）是一种使人衰弱的疾病，会导致进行性的功能损害。由于中枢神经系统中轴突再生有限，患者几乎无法恢复或恢复甚微。在脊髓损伤动物模型中研究了不同的细胞和分子方法。干细胞的细胞移植有可能替代受损组织，并为轴突再生提供合适的微环境。在此，我们回顾了我们的同事及其他人应用的最新方法，以促进脊髓损伤后的轴突再生。我们通过不同方法使用了不同类型的干细胞。首先，将胎儿嗅黏膜、雪旺细胞和骨髓基质细胞移植到脊髓损伤模型的损伤部位。在后来的研究中，借助纳米颗粒在脊髓损伤模型中同时进行干细胞与软骨素酶ABC的移植。使用这些方法，观察到了显著的功能恢复。然而，考虑到干细胞治疗中的一些挑战，如排斥反应、感染和新发癌症，我们最近的策略是应用细胞因子。当使用基质衍生因子-1将内源性干细胞吸引到损伤部位时，我们观察到大鼠的运动功能有显著改善。总之，通过新的递送系统将不同细胞与酶和生长因子等其他因素共同移植，在脊髓损伤中似乎可能产生更好的效果。
