利鲁唑改善大鼠中哈马灵诱导的震颤。
Riluzole Ameliorates Harmaline-induced Tremor in Rat.
作者信息
Shourmasti Fatemeh Rahimi, Goudarzi Iran, Abrari Kataneh, Salmani Mahmoud Elahdadi, Laskarbolouki Taghi
机构信息
School of Biology, Damghan University, Damghan,Iran ; Institute of Biological Sciences, Damghan University, Damghan, Iran.
出版信息
Basic Clin Neurosci. 2014 Spring;5(2):138-43.
INTRODUCTION
Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat.
METHODS
Four groups of Wistar rats weighing 80-100 g were injected with harmaline (30 mg/ kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/ kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded.
RESULTS
The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor.
DISCUSSION
It is concluded that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats.
引言
在 harmaline 诱发的震颤期间，橄榄小脑爆发性放电过多。我们假设抗谷氨酸能药物会抑制 harmaline 震颤。从这一观点出发，本研究的目的是探讨利鲁唑对大鼠 harmaline 诱发震颤的影响。
方法
将四组体重 80 - 100 g 的 Wistar 大鼠注射 harmaline（30 mg/kg 腹腔注射）以诱发实验性震颤。第 1 组大鼠作为对照，而第 2、3 和 4 组动物在 harmaline 给药前 30 分钟和给药后 90 分钟也腹腔注射利鲁唑，剂量分别为 2、4 和 8 mg/kg。记录震颤的起始潜伏期、强度和持续时间。
结果
本研究结果表明，利鲁唑可显著延长潜伏期，并减少震颤的持续时间和强度。
讨论
得出结论，利鲁唑预处理可改善大鼠 harmaline 诱发的震颤。
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