抗利尿激素对慢性插管绵羊胎儿尿流和成分的影响。

The effects of antidiuretic hormone on urine flow and composition in the chronically-cannulated ovine fetus.

作者信息

Lingwood B, Hardy K J, Horacek I, McPhee M L, Scoggins B A, Wintour E M

出版信息

Q J Exp Physiol Cogn Med Sci. 1978 Oct;63(4):315-30. doi: 10.1113/expphysiol.1978.sp002445.

DOI:10.1113/expphysiol.1978.sp002445

Abstract

The fetuses of nine pregnant ewes were chronically cannulated between 86 and 130 days with cannulae in one carotid artery, one jugular vein, the fetal bladder and the amniotic cavity. The effects of infused AVP on fetal urine flow rate and composition were studied. A dose of 35 pmol. h-1 always caused an increase in urine osmolality and a decrease in flow rate and free water clearance without change in blood pressure. Higher doses (140 pmol.h-1) were significantly pressor and caused increased excretion of sodium, chloride, urea and creatinine. Although this dose always caused an increase in urine osmolality, in five experiments the flow rate also rose. It is concluded that the ovine fetus has the ability to control its own urine flow and composition, and possibly also amniotic fluid volume and composition.

摘要

在妊娠86至130天期间，对9只怀孕母羊的胎儿进行长期插管，将插管分别置于一条颈动脉、一条颈静脉、胎儿膀胱和羊膜腔内。研究了注入抗利尿激素（AVP）对胎儿尿流率和尿液成分的影响。35皮摩尔·小时⁻¹的剂量总是会导致尿渗透压升高，流速和自由水清除率降低，而血压无变化。更高剂量（140皮摩尔·小时⁻¹）具有显著的升压作用，并导致钠、氯、尿素和肌酐的排泄增加。尽管此剂量总是会使尿渗透压升高，但在5次实验中流速也有所上升。得出的结论是，绵羊胎儿有能力控制自身的尿流和尿液成分，也可能控制羊水的体积和成分。