Chaturvedi Shubhra, Mishra Anil Kumar
Department of Radiopharmaceuticals, Institute of Nuclear Medicine & Allied Sciences (INMAS), New Delhi, India.
Ther Deliv. 2014 Aug;5(8):893-912. doi: 10.4155/tde.14.57.
Internal radiation using radiopharmaceuticals promises efficient cancer therapeutics. The specificity and selectivity required for screening and pinpointing tumor cells for cell-kill has been made possible by targeted ligands based on 'magic bullet' and tracer principle- theories nearing a century. Overexpression of certain receptors has been exploited using biomolecules for targeting. The pragmatic analysis, however, is not as promising compared with the theoretical knowledge of available gamut of vectors and targets. The complex interplay of in vitro and in vivo parameters, and the effect of radionuclides involve a systematic assessment of radiopharmaceuticals as diagnostic and therapeutic agent. This review presents different vectors with their pros and cons, present status and recent design variations followed by a future perspective based on novel approaches.
使用放射性药物进行内照射有望实现高效的癌症治疗。基于“神奇子弹”和示踪原理（这些理论已近一个世纪）的靶向配体，使得筛选和精准定位肿瘤细胞以进行细胞杀伤所需的特异性和选择性成为可能。利用生物分子靶向某些受体的过表达。然而，与现有一系列载体和靶点的理论知识相比，实际分析并不那么乐观。体外和体内参数的复杂相互作用以及放射性核素的影响涉及对放射性药物作为诊断和治疗剂的系统评估。本综述介绍了不同载体的优缺点、现状和最近的设计变化，随后基于新方法展望了未来前景。
