State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai, 201203, China.
Org Lett. 2014 Nov 7;16(21):5686-9. doi: 10.1021/ol502751k. Epub 2014 Oct 22.
A facile and efficient synthetic strategy to 3-((trifluoromethyl)thio)-4H-chromen-4-one was developed. AgSCF3 and trichloroisocyanuric acid were employed here to generate active electrophilic trifluoromethylthio species in situ. This reaction could proceed under mild conditions in a short reaction time and be insensitive to air and moisture.
开发了一种简便高效的 3-((三氟甲基)硫代)-4H-色烯-4-酮合成策略。该策略采用 AgSCF3 和三氯异氰尿酸原位生成活性亲电三氟甲硫基物种。该反应可以在温和的条件下短时间内进行，并且对空气和水分不敏感。
