Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288, Marseille, France.
Org Biomol Chem. 2015 Jan 7;13(1):110-4. doi: 10.1039/c4ob01836b.
Various arylvinyltriazole nucleoside analogues were synthesized using Pd-catalyzed oxidative Heck reaction. This method affords the corresponding and otherwise difficult to achieve arylvinyltriazole nucleosides with good yields and large functional group compatibility. These results further advocate the potential and practicality of this oxidative C-H alkenylation method for generating structurally challenging chemical entities in organic synthesis.
使用钯催化的氧化 Heck 反应合成了各种芳基乙烯基三唑核苷类似物。该方法以良好的收率和较大的官能团相容性提供了相应的且难以获得的芳基乙烯基三唑核苷。这些结果进一步证明了这种氧化 C-H 烯丙基化方法在有机合成中生成结构具有挑战性的化学实体的潜力和实用性。
