Cousins Alex R O, Ritson Dougal, Sharma Pallavi, Stevens Malcolm F G, Moses John E, Searle Mark S
Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, UK.
Chem Commun (Camb). 2014 Dec 14;50(96):15202-5. doi: 10.1039/c4cc07487d.
Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.
对三种人类端粒重复序列（d(AGGG(TTAGGG)n，n = 3、7和11)）与配体相互作用的生物物理研究表明，一种基于恶唑的“点击”配体可诱导平行折叠的四链体，它优先稳定更长的端粒重复序列，这为在串联四链体基序之间的界面处结合的选择性提供了证据。
