Colthup P V, Palmer J L
Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
Eur J Cancer Clin Oncol. 1989;25 Suppl 1:S71-4.
High performance liquid chromatography has been found to be an accurate method for determination of ondansetron in plasma. Within a single assay, and between assays, the differences between theoretical and observed means obtained from analysis of spiked samples were low and good precision was obtained. The method has been used to assay several thousand samples from subjects included in pharmacokinetic studies. The pharmacokinetic profile of ondansetron has been established following single and multiple oral dosing and intravenous infusions.
高效液相色谱法已被证明是测定血浆中昂丹司琼的准确方法。在单次测定以及不同次测定之间，加标样品分析所得理论均值与观测均值之间的差异较小，且精密度良好。该方法已用于药代动力学研究中数千例受试者样本的分析。在单次和多次口服给药以及静脉输注后，已确定了昂丹司琼的药代动力学特征。
