Heinkele Georg, Geditz Mirjam C K, Ganchev Boian, Kerb Reinhold, Hofmann Ute, Mürdter Thomas E
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstrasse 112, 70376 Stuttgart, Germany.
J Labelled Comp Radiopharm. 2014 Oct;57(12):699-703. doi: 10.1002/jlcr.3243. Epub 2014 Oct 22.
A new reaction pathway for the synthesis of a [(2)H]-labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope-labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.
描述了一种用于合成用于制备葡糖醛酸苷的[(2)H]标记的三氯乙酰亚胺酯前体的新反应途径。由此，可以在制备规模上获得稳定同位素标记的药物葡糖醛酸苷，其可进一步用作定量分析的内标。
