Gârban Z, Daranyi G, Borza-Teicu I, Nemeş R, Precob V
Morphol Embryol (Bucur). 1989 Oct-Dec;35(4):289-95.
The possible late maternal effect on biochemical homeostasis of acute administration of ethanol during the preimplantation period was studied on pregnant albino female rats (Wistar strain). Females were injected i.v. with a 33.16% (v/v) solution of ethanol (4.80 ml/kg body weight) on day 2 and 4 of pregnancy, the animals being sacrificed on day 20. The effects on hepatic DNA biosynthesis and on some serum metabolites (proteins, lipids and some non-protein nitrogen compounds) were determined in the treated and in an untreated control group. In the treated group a non-significant increase of hepatic DNA concentration was found. Homeostasis changes of serum proteins involved: a slight increase of total serum protein content, hypoalbuminemia and hyperglobulinemia (non-significant values). Lipid metabolites showed also non-significant changes: increase of total lipids and decrease of cholesterol. Uric acid and urea (non-protein metabolites) concentration was increased. This increase, in spite of its significance level, must be taken into account and may be due to the presence of dead fetuses and to the consecutive renal lesions.
在怀孕的白化雌性大鼠（Wistar品系）身上研究了着床前期急性给予乙醇对母体后期生化稳态的可能影响。在怀孕第2天和第4天，给雌性大鼠静脉注射33.16%（v/v）的乙醇溶液（4.80毫升/千克体重），在第20天处死动物。测定了处理组和未处理对照组对肝脏DNA生物合成以及一些血清代谢物（蛋白质、脂质和一些非蛋白氮化合物）的影响。在处理组中，发现肝脏DNA浓度有不显著的增加。血清蛋白质的稳态变化包括：血清总蛋白含量略有增加、低白蛋白血症和高球蛋白血症（数值无统计学意义）。脂质代谢物也有不显著的变化：总脂质增加，胆固醇减少。尿酸和尿素（非蛋白代谢物）浓度增加。尽管这种增加的显著水平不高，但必须予以考虑，这可能是由于死胎的存在以及随之而来的肾脏病变所致。
