左乙拉西坦可改善非惊厥性癫痫持续状态的抑制解除行为。
Levetiracetam improves disinhibitory behavior in nonconvulsive status epilepticus.
机构信息
Department of Psychiatry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8522 Nara Japan.
Department of Neurosurgery, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8522 Nara Japan.
出版信息
Ann Gen Psychiatry. 2014 Oct 14;13(1):32. doi: 10.1186/s12991-014-0032-0. eCollection 2014.
BACKGROUND
Nonconvulsive status epilepticus (NCSE) is a severe medical condition and heterogeneous disorder defined by different seizure types and diverse etiologies. NCSE occurs commonly in the elderly and is potentially misdiagnosed as a psychiatric disorder. Current treatment options for NCSE are still unsatisfactory.
CASE PRESENTATION
We report a case of NCSE in a 55-year-old epileptic male patient with a history of infectious encephalitis, disinhibitory behavior, and a suspected diagnosis of frontotemporal dementia. Add-on levetiracetam (LEV) to carbamazepine treatment improved clinical manifestations and abnormal electroencephalographic discharge.
CONCLUSION
With disinhibitory behavior in the elderly, the possibility of NCSE should be considered. Moreover, LEV may be an effective and well-tolerated pharmacotherapy for elderly NCSE patients.
背景
非惊厥性癫痫持续状态（NCSE）是一种严重的医学病症，具有多种癫痫发作类型和不同病因的异质性疾病。NCSE 在老年人中较为常见，且可能被误诊为精神障碍。目前，NCSE 的治疗选择仍不理想。
病例介绍
我们报告了一例 55 岁癫痫男性患者的 NCSE 病例，该患者既往有感染性脑炎病史，表现为行为失抑制，疑似 frontotemporal 痴呆。加用左乙拉西坦（LEV）治疗卡马西平后，患者的临床表现和异常脑电图放电均得到改善。
结论
对于老年患者出现行为失抑制，应考虑 NCSE 的可能。此外，LEV 可能是治疗老年 NCSE 患者的一种有效且耐受良好的药物治疗方法。
Zotero 插件