规律血液透析患者中钙磷乘积与血清C反应蛋白水平的关联
Association of Ca×PO4 product with levels of serum C-reactive protein in regular hemodialysis patients.
作者信息
Nasri Hamid
机构信息
Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
出版信息
J Renal Inj Prev. 2012 Sep 1;1(2):55-9. doi: 10.12861/jrip.2012.20. eCollection 2012.
INTRODUCTION
Numerous studies have attempted to identify risk factors for mortality and morbidity in maintenance hemodialysis patients. In this study we sought to examine the association of the levels of serum C-reactive protein (CRP) with value of Ca×PO4 product, in stable hemodialysis patients.
PATIENTS AND METHODS
Based on the severity of secondary hyperparathyroidism, patients being treated with oral active vitamin D3, calcium carbonate/Renagel tablets at various doses. Fasting serum 25-hydroxy vitamin D and intact serum parathormone and also serum blood urea nitrogen, CRP, calcium, phosphorus, alkaline phosphatase was measured.
RESULTS
A total of 41 patients, enrolled to the study. The mean patients' age were 46(17.6) years. The value of serum CRP of patients was 8.6 (6.6) mg/l (median 6 mg/l). The value of Ca×PO4 product was 50.5(15.5) mg2/dl2 (median: 50 mg(2)/dl(2)). In this study, a significant inverse association between Ca×PO4 product and the age of the patients was seen. A significant positive correlation of logarithm of serum CRP with Ca×PO4 product was found.
CONCLUSION
The result of this study, revealed the need to further attention to hyperphosphatemia in hemodialysis patients.
引言
众多研究试图确定维持性血液透析患者死亡率和发病率的危险因素。在本研究中，我们旨在探讨稳定血液透析患者血清C反应蛋白（CRP）水平与钙磷乘积值之间的关联。
患者与方法
根据继发性甲状旁腺功能亢进的严重程度，患者接受不同剂量的口服活性维生素D3、碳酸钙/司维拉姆片治疗。检测空腹血清25-羟维生素D、完整血清甲状旁腺激素以及血清血尿素氮、CRP、钙、磷、碱性磷酸酶。
结果
共有41例患者纳入本研究。患者的平均年龄为46（17.6）岁。患者血清CRP值为8.6（6.6）mg/l（中位数6mg/l）。钙磷乘积值为50.5（15.5）mg²/dl²（中位数：50mg²/dl²）。在本研究中，观察到钙磷乘积与患者年龄之间存在显著的负相关。发现血清CRP对数与钙磷乘积之间存在显著正相关。
结论
本研究结果表明，需要进一步关注血液透析患者的高磷血症。
Zotero 插件