Itoh Y, Fukunaga Y, Yamamoto M
Arerugi. 1989 Nov;38(11):1276-87.
Using a novel technique previously described for measuring erythrocyte C3b receptors (E-CR1) by means of flow cytometry, we studied E-CR1 levels in patients with various diseases. We also measured C3b receptors of B cells (B-CR1) by flow cytometry, and studied the correlation between E-CR1 levels and B-CR1 levels. We have found; 1) Decreased E-CR1 levels were seen in patients with active SLE, acute leukemia, and congenital immunodeficiency syndrome. E-CR1 levels in patients with IgA nephropathy, membranoproliferative glomerulonephritis, anaphylactoid purpura, infectious mononucleosis, and viral pneumonia were statistically higher than those in normal controls. 2) Decreased E-CR1 levels in some patients with SLE were not thought to be inherited, but the E-CR1 levels of patients with diseases other than SLE appeared to be regulated in an autosomal co-dominant form of inheritance. 3) A negative correlation was observed between E-CR1 levels and B-CR1 levels in both patients with SLE and normal controls.
我们使用一种先前描述的通过流式细胞术测量红细胞C3b受体（E-CR1）的新技术，研究了各种疾病患者的E-CR1水平。我们还通过流式细胞术测量了B细胞的C3b受体（B-CR1），并研究了E-CR1水平与B-CR1水平之间的相关性。我们发现：1）活动性系统性红斑狼疮（SLE）、急性白血病和先天性免疫缺陷综合征患者的E-CR1水平降低。IgA肾病、膜增生性肾小球肾炎、过敏性紫癜、传染性单核细胞增多症和病毒性肺炎患者的E-CR1水平在统计学上高于正常对照组。2）一些SLE患者E-CR1水平降低被认为不是遗传性的，但除SLE外其他疾病患者的E-CR1水平似乎以常染色体共显性遗传形式受到调控。3）SLE患者和正常对照组的E-CR1水平与B-CR1水平之间均观察到负相关。
