Chen G, Zhang K Z, Liao Z H, Wang S H, Ma S J, Long Z Z, Tian W T, Zhu J Y
Chin Med J (Engl). 1989 Sep;102(9):698-701.
Peripheral T lymphocyte subsets in 60 cases of Graves' disease (GD) and 16 cases of Hashimoto's thyroiditis (HT) were determined by the use of OKT monoclonal antibodies (McAb). The results showed that in both diseases OKT3 cells (total T cells) and OKT8 cells (suppressor T cells, TS cells) were lower and the ratio of OKT4 cells (helper T cells, TH cells) OKT8 cells was much higher than those in normal controls. GD patients who were treated with antithyroid drugs (ATD) and whose serum T3, T4 recovered to normal, could be further divided into subgroups of high OKT4/OKT8 cell ratio and of normal ratio. The pathogenesis, treatment and relapse of autoimmune thyroid diseases (AITD) were discussed in this paper on the basis of the results.
应用OKT单克隆抗体（McAb）检测60例格雷夫斯病（GD）和16例桥本甲状腺炎（HT）患者的外周血T淋巴细胞亚群。结果显示，两种疾病患者的OKT3细胞（总T细胞）和OKT8细胞（抑制性T细胞，TS细胞）均减少，OKT4细胞（辅助性T细胞，TH细胞）与OKT8细胞的比值显著高于正常对照组。接受抗甲状腺药物（ATD）治疗且血清T3、T4恢复正常的GD患者，可进一步分为OKT4/OKT8细胞比值高和比值正常的亚组。本文根据上述结果对自身免疫性甲状腺疾病（AITD）的发病机制、治疗及复发情况进行了讨论。
