[CD40基因多态性与川崎病冠状动脉病变的相关性]

[Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease].

作者信息

Cheng Shou-Chao, Cheng Yan-Yang, Wu Jin-Long

机构信息

Department of Pediatrics, Xianning Central Hospital, Xianning, Hubei 437100, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2014 Oct;16(10):1025-8.

PMID:25344184

Abstract

OBJECTIVE

To study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children.

METHODS

A case-control study was performed on 184 children with KD and 206 normal controls. The polymorphisms of two SNPs in CD40 gene were detected using PCR-RFLP.

RESULTS

There were no significant differences in the genotype distribution and allele frequency of SNP rs4810485 in CD40 gene between the KD and normal groups (P>0.05). The genotype distribution of SNP rs1535045 in CD40 gene in the KD group was significantly different from the control group (P<0.05). T allele of SNP rs1535045 was shown as a risk factor for development of KD (OR=1.592, 95%CI: 1.182-2.144, P=0.004). There were no association between the polymorphisms of the two SNPs and coronary artery lesions (P>0.05).

CONCLUSIONS

SNP rs1535045 may be associated with the development of KD in Han Chinese children, while SNP rs4810485 may not.

摘要

目的

研究汉族儿童中两个单核苷酸多态性（CD40基因中的rs4810485和rs1535045）与川崎病（KD）之间的关联。

方法

对184例KD患儿和206例正常对照进行病例对照研究。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测CD40基因中两个单核苷酸多态性（SNP）。

结果

KD组与正常组CD40基因SNP rs4810485的基因型分布和等位基因频率无显著差异（P>0.05）。KD组CD40基因SNP rs1535045的基因型分布与对照组有显著差异（P<0.05）。SNP rs1535045的T等位基因被证明是KD发生的危险因素（比值比=1.592，95%可信区间：1.182-2.144，P=0.004）。两个SNP的多态性与冠状动脉病变之间无关联（P>0.05）。