Li Feng, Sheng Xiao-Yang
Department of Child and Adolescent Healthcare, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute for Pediatric Research, MOE-Shanghai Key Laboratory of Children′s Environmental Health, Shanghai 200092, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2014 Oct;16(10):1064-9.
Calprotectin is a calcium- and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity. This paper reviews current findings concerning the relationship between faecal calprotectin and intestinal development among children, influencing factors of fecal calprotectin and the implication of faecal calprotectin in the diagnosis, follow-up, assessment of relapses, and response to treatment in pediatric intestinal diseases, such as necrotizing enterocolitis, inflammatory bowel disease, intestinal infection, celiac disease and allergy. Further studies are required to provide insights into the actual role of calprotectin in physiological and pathological processes in pediatrics.
钙卫蛋白是S100家族的一种钙结合和锌结合蛋白，主要由中性粒细胞表达，具有重要的细胞外活性。本文综述了目前关于儿童粪便钙卫蛋白与肠道发育之间关系的研究结果、粪便钙卫蛋白的影响因素，以及粪便钙卫蛋白在儿科肠道疾病（如坏死性小肠结肠炎、炎症性肠病、肠道感染、乳糜泻和过敏）的诊断、随访、复发评估及治疗反应中的意义。还需要进一步研究以深入了解钙卫蛋白在儿科生理和病理过程中的实际作用。
