坏死性小肠结肠炎早产儿粪便钙卫蛋白升高。
Increased fecal calprotectin in preterm infants with necrotizing enterocolitis.
作者信息
Aydemir Gokhan, Cekmez Ferhat, Tanju I Asya, Canpolat Fuat Emre, Genc F Alparslan, Yildirim Sukran, Tunc Turan, Sarici S Umit
机构信息
Department ofPediatrics, GATA Medical Faculty, Istanbul, Turkey.
出版信息
Clin Lab. 2012;58(7-8):841-4.
BACKGROUND
Necrotizing entrocolitis (NEC) remains a potentially fatal disease in premature infants despite the recent advances in neonatal care. It is a disease with a multifactorial etiology leading to the one common final pathway of necrosis and inflammmation of the neonatal intestine.
METHODS
Calprotectin is a calcium and zinc-binding protein in human neutrophils. Its concentration rises in various organic bowel diseases in adults and is resistant to degradation and has been proposed as a useful, simple, and rapid diagnostic method of inflammatory bowel disease that shows gastrointestinal inflammation in children and adults.
RESULTS
We found that infants with necrotizing enterocolitis had increased fecal calprotectin concentrations, and there was a correlation between calprotectin concentrations and severity of NEC.
CONCLUSIONS
We concluded that fecal calprotectin is a useful marker for diagnosis and severity of NEC in preterm infants.
背景
尽管新生儿护理方面最近取得了进展，但坏死性小肠结肠炎（NEC）在早产儿中仍然是一种潜在的致命疾病。它是一种病因多因素的疾病，导致新生儿肠道坏死和炎症这一共同的最终途径。
方法
钙卫蛋白是人类中性粒细胞中的一种钙结合和锌结合蛋白。其浓度在成人的各种器质性肠道疾病中会升高，并且抗降解，已被提议作为一种有用、简单且快速的炎症性肠病诊断方法，可显示儿童和成人的胃肠道炎症。
结果
我们发现患有坏死性小肠结肠炎的婴儿粪便钙卫蛋白浓度升高，且钙卫蛋白浓度与NEC的严重程度之间存在相关性。
结论
我们得出结论，粪便钙卫蛋白是早产儿NEC诊断和严重程度的有用标志物。
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