Patel Prashanth, Davies Timothy, Madira Webster, Gupta Pankaj
Department of Chemical Pathology, University Hospitals of Leicester NHS Trust, Leicester, UK.
Department of Chemical Pathology, University Hospitals of Leicester NHS Trust, Leicester, UK
Ann Clin Biochem. 2015 Jul;52(Pt 4):502-5. doi: 10.1177/0004563214559221. Epub 2014 Oct 24.
Lipoprotein(a) is an independent predictor of cardiovascular disease and its variability after myocardial infarction was assessed in this study.
Lipoprotein(a) was analysed by a size insensitive latex immunoturbidimetric end point assay in samples from days 0 to 7 in 31 patients admitted with myocardial infarction.
Median lipoprotein(a) changed by -0.9%, -0.1% and 9.6% on days 1, 2-3 and 4-7, respectively, and was not statistically significant. Median total cholesterol reduced by 8.7%, 9.1%, 14.5% and C-reactive protein increased by 68.4%, 510%, 502% over days 1, 2-3, 4-7, respectively.
Unlike total cholesterol and C-reactive protein, lipoprotein(a) does not demonstrate significant variability for up to seven days after myocardial infarction and measurements made during this period after myocardial infarction are physiologically meaningful.
脂蛋白(a)是心血管疾病的独立预测因子，本研究评估了心肌梗死后其变异性。
采用对大小不敏感的乳胶免疫比浊终点法，对31例心肌梗死入院患者第0至7天的样本进行脂蛋白(a)分析。
脂蛋白(a)中位数在第1天、第2 - 3天和第4 - 7天分别变化了-0.9%、-0.1%和9.6%，差异无统计学意义。总胆固醇中位数在第1天、第2 - 3天、第4 - 7天分别降低了8.7%、9.1%、14.5%，C反应蛋白分别升高了68.4%、510%、502%。
与总胆固醇和C反应蛋白不同，脂蛋白(a)在心肌梗死后长达7天内未表现出显著变异性，在此期间进行的测量具有生理意义。
