Krysiak Robert, Szkróbka Witold, Okopień Boguslaw
Przegl Lek. 2014;71(6):352-4.
In the light of the recent studies it seems that traumatic brain injury-induced pituitary hormones deficiency occurs much more frequently than previously thought. Anterior pituitary hormone dysfunction may be an important feature of long-term morbidity in survivors of traumatic brain injury. The most common alterations appear to be somatotropin and gonadotropin deficiency, followed by corticotropin and thyrotropin deficiency. Clinical signs of hypopituitarism are, however, often subtle and may be masked by sequalae of traumatic brain injury, causing that the partial or complete insufficiency of anterior pituitary secretion may be underrecognized. Patients suffering from this condition may benefit from appropriate hormone replacement therapy. The authors report a case of a young male patient who developed hypogonadism and hyperprolactinemia several months after an accident. This case illustrates the need for clinical awareness of pituitary dysfunction in patients after traumatic brain injury.
根据最近的研究，创伤性脑损伤所致垂体激素缺乏的发生频率似乎比之前认为的要高得多。垂体前叶激素功能障碍可能是创伤性脑损伤幸存者长期发病的一个重要特征。最常见的改变似乎是生长激素和促性腺激素缺乏，其次是促肾上腺皮质激素和促甲状腺激素缺乏。然而，垂体功能减退的临床症状往往很细微，可能会被创伤性脑损伤的后遗症所掩盖，导致垂体前叶分泌的部分或完全不足可能未被充分认识。患有这种疾病的患者可能会从适当的激素替代治疗中受益。作者报告了一例年轻男性患者，该患者在事故发生数月后出现性腺功能减退和高催乳素血症。这个病例说明了创伤性脑损伤患者垂体功能障碍的临床意识的必要性。
