Palladium-catalyzed carbonylative reactions of 1-bromo-2-fluorobenzenes with various nucleophiles: effective combination of carbonylation and nucleophilic substitution.

A systematic study on the carbonylative transformation of 1-bromo-2-fluorobenzenes with various nucleophiles has been performed. Different types of double nucleophiles, such as NN, NC, OC, and NS, can be effectively applied as coupling partners. The corresponding six-membered heterocycles were isolated in moderate to good yields.