Tsai S-C, Ou Y-C, Cheng C-L, Li J-R, Lin Y-C, Ho H-C, Chiu K-Y, Su C-K, Lin W-Y
Wan-Yu Lin, MD, Department of Nuclear Medicine, Taichung Veterans General Hospital, 1650, Taiwan Boulevard, Sec. 4, Taichung 407, Taiwan, Tel. (886)4/23 74 13 49, Fax (886)4/23 74 13 48, E-mail:
Nuklearmedizin. 2015;54(1):36-42. doi: 10.3413/Nukmed-0652-14-03. Epub 2014 Oct 27.
Oral hydration with large volume of fluid, high dose of diuretics and maximum bladder distension are frequently required to achieve an adequate urinary FDG clearance in an FDG PET/CT protocol for bladder cancer or pelvic tumour evaluation. Although most patients tolerated these procedures for eliminating urinary FDG activity, these procedures may be still unpleasant.
Is there a more patient-friendly protocol which is less burdensome and yet provides a satisfactory FDG clearance in urine? In this study, we established a patient-friendly FDG PET/CT protocol without compromising urinary FDG clearance.
PATIENTS, METHODS: 23 patients with biopsy-proven urinary bladder cancers were recruited to evaluate the effectiveness of this patient-friendly protocol on reducing urinary bladder FDG activity. The patient-friendly protocol includes encouraging patients to take a tolerable amount of fluid, delaying the administration of low dose diuretic, shortening the urine holding time and using delayed imaging.
All of the patients tolerated this patient-friendly procedure well. In addition, the patient-friendly protocol was effective in reducing FDG activity in the urine. One hundred percent of primary bladder cancer were visualized on the FDG PET/CT images using this patient-friendly protocol.
This patient-friendly FDG PET/CT protocol is less intrusive yet effective in reducing urinary FDG activity.
在用于膀胱癌或盆腔肿瘤评估的FDG PET/CT检查方案中，通常需要大量口服补液、大剂量利尿剂以及使膀胱最大限度充盈，以实现足够的尿液FDG清除。尽管大多数患者能够耐受这些清除尿液中FDG活性的操作，但这些操作仍可能会让患者感到不适。
是否存在一种对患者更友好的方案，既能减轻负担，又能在尿液中实现令人满意的FDG清除？在本研究中，我们建立了一种对患者友好的FDG PET/CT检查方案，同时不影响尿液中FDG的清除。
患者、方法：招募了23例经活检证实为膀胱癌的患者，以评估这种对患者友好的方案在降低膀胱FDG活性方面的有效性。对患者友好的方案包括鼓励患者摄入可耐受量的液体、延迟给予低剂量利尿剂、缩短憋尿时间以及采用延迟成像。
所有患者对这种对患者友好的操作耐受性良好。此外，该对患者友好的方案在降低尿液中FDG活性方面有效。使用这种对患者友好的方案，100%的原发性膀胱癌在FDG PET/CT图像上得以显示。
这种对患者友好的FDG PET/CT检查方案侵入性较小，但在降低尿液中FDG活性方面有效。
