Lee Yun-Gyoo, Bang Soo-Mee, Lee Jeong-Ok, Kim Jin Won, Lee Keun-Wook, Kim Jee Hyun, Song Jung Han, Kim Tae-Hee, Kim Ki Woong, Lee Jong-Seok
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea ; Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Cancer Res Treat. 2015 Apr;47(2):215-20. doi: 10.4143/crt.2013.262. Epub 2014 Aug 29.
We previously reported the prevalence of monoclonal gammopathy of undetermined significance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during 2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUS cohort.
The 680 participants from the initial cohort were followed-up for a median of 5 years. Sera were collected between 2010 and 2011. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal-protein (M-protein).
Of the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-up study and 10 were found to have MGUS. Among the 21 MGUS patients initially identified, nine were followed-up, six had persistent M-protein, and one patient had progressed to multiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remaining two individuals. Among the 339 participants without MGUS who were followed-up, four developed an M-protein. There was no significant difference in survival with respect to the presence of MGUS (p=0.66).
The 5-year follow-up data show that the natural clinical course of MGUS in Korea is similar to that in Western countries. MGUS was not associated with an increased risk of death over the 5-year study period.
我们之前报道了在2005 - 2006年招募的韩国老年城市队列中意义未明的单克隆丙种球蛋白病（MGUS）的患病率为3.3%。在此，我们报告对先前确定的MGUS队列进行的5年随访研究。
对初始队列中的680名参与者进行了中位时间为5年的随访。在2010年至2011年期间收集血清。采用标准血清电泳进行两步筛查，随后进行免疫固定和单克隆蛋白（M蛋白）血清浓度测定。
在680名参与者（21名患有MGUS）中，348名（51%）同意参与随访研究，其中10名被发现患有MGUS。在最初确定的21名MGUS患者中，9名接受了随访，6名M蛋白持续存在，1名患者进展为多发性骨髓瘤（进展率为1.0%/年）。其余两名个体的M蛋白消失。在339名未患MGUS且接受随访的参与者中，有4人出现了M蛋白。MGUS的存在与否在生存率方面无显著差异（p = 0.66）。
5年随访数据表明，韩国MGUS的自然临床病程与西方国家相似。在5年研究期间，MGUS与死亡风险增加无关。
